Reproductive and menstrual factors and risk of colorectal cancer

E. Negri, C. La Vecchia, F. Parazzini, R. Savoldelli, A. Gentile, B. D'Avanzo, A. Gramenzi, S. Franceschi

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The relation between reproductive and menstrual factors and the risk of colorectal cancer was investigated in a case-control study conducted in Northern Italy on 279 women with colon cancer, 153 with rectal cancer and 386 controls admitted to hospital for a wide spectrum of acute, nonneoplastic, nondigestive disorders. Compared with nulliparous women, the relative risks (RR) of colon cancer were 1.1 for one and two births, 1.3 for three or four, and 1.1 for five or more. Corresponding values for rectal cancer were 0.9 for one, 1.1 for two, 1.4 for three or four, and 0.8 for five or more births. No significant association emerged with number of abortions, and no consistent pattern of trends for both colon and rectum cancer was observed in relation to age at first or last birth. Women whose menarche occurred at age 15 or over were at significantly lower risk of colon cancer (RR 0.5, 95% confidence interval = 0.3-0.9), and the point estimate was below unity, though nonsignificantly, for rectal cancer too (RR = 0.7). There was no relation between age at menopause, duration of menstrual cycles, and cancers of the colon and rectum. The present study produced no evidence that reproductive factors are related to colorectal cancer in this population. With this sample size, it was possible to exclude relative risks below 0.8 for colon and 0.7 for rectal cancer among multiparous women versus nulliparous ones. These findings are thus inconsistent with the epidemiological evidence on reproductive and menstrual factors and breast cancer in this and other populations, with the sole potential exception of the reduced risk of colorectal cancer among women whose menarche occurred at age 15 or over.

Original languageEnglish
Pages (from-to)7158-7161
Number of pages4
JournalCancer Research
Volume49
Issue number24 I
Publication statusPublished - 1989

Fingerprint

Rectal Neoplasms
Colorectal Neoplasms
Colonic Neoplasms
Menarche
Parturition
Menstrual Cycle
Menopause
Sample Size
Italy
Population
Case-Control Studies
Colon
Confidence Intervals
Breast Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Negri, E., La Vecchia, C., Parazzini, F., Savoldelli, R., Gentile, A., D'Avanzo, B., ... Franceschi, S. (1989). Reproductive and menstrual factors and risk of colorectal cancer. Cancer Research, 49(24 I), 7158-7161.

Reproductive and menstrual factors and risk of colorectal cancer. / Negri, E.; La Vecchia, C.; Parazzini, F.; Savoldelli, R.; Gentile, A.; D'Avanzo, B.; Gramenzi, A.; Franceschi, S.

In: Cancer Research, Vol. 49, No. 24 I, 1989, p. 7158-7161.

Research output: Contribution to journalArticle

Negri, E, La Vecchia, C, Parazzini, F, Savoldelli, R, Gentile, A, D'Avanzo, B, Gramenzi, A & Franceschi, S 1989, 'Reproductive and menstrual factors and risk of colorectal cancer', Cancer Research, vol. 49, no. 24 I, pp. 7158-7161.
Negri E, La Vecchia C, Parazzini F, Savoldelli R, Gentile A, D'Avanzo B et al. Reproductive and menstrual factors and risk of colorectal cancer. Cancer Research. 1989;49(24 I):7158-7161.
Negri, E. ; La Vecchia, C. ; Parazzini, F. ; Savoldelli, R. ; Gentile, A. ; D'Avanzo, B. ; Gramenzi, A. ; Franceschi, S. / Reproductive and menstrual factors and risk of colorectal cancer. In: Cancer Research. 1989 ; Vol. 49, No. 24 I. pp. 7158-7161.
@article{49573848c52d4987b4bcaca5868a1988,
title = "Reproductive and menstrual factors and risk of colorectal cancer",
abstract = "The relation between reproductive and menstrual factors and the risk of colorectal cancer was investigated in a case-control study conducted in Northern Italy on 279 women with colon cancer, 153 with rectal cancer and 386 controls admitted to hospital for a wide spectrum of acute, nonneoplastic, nondigestive disorders. Compared with nulliparous women, the relative risks (RR) of colon cancer were 1.1 for one and two births, 1.3 for three or four, and 1.1 for five or more. Corresponding values for rectal cancer were 0.9 for one, 1.1 for two, 1.4 for three or four, and 0.8 for five or more births. No significant association emerged with number of abortions, and no consistent pattern of trends for both colon and rectum cancer was observed in relation to age at first or last birth. Women whose menarche occurred at age 15 or over were at significantly lower risk of colon cancer (RR 0.5, 95{\%} confidence interval = 0.3-0.9), and the point estimate was below unity, though nonsignificantly, for rectal cancer too (RR = 0.7). There was no relation between age at menopause, duration of menstrual cycles, and cancers of the colon and rectum. The present study produced no evidence that reproductive factors are related to colorectal cancer in this population. With this sample size, it was possible to exclude relative risks below 0.8 for colon and 0.7 for rectal cancer among multiparous women versus nulliparous ones. These findings are thus inconsistent with the epidemiological evidence on reproductive and menstrual factors and breast cancer in this and other populations, with the sole potential exception of the reduced risk of colorectal cancer among women whose menarche occurred at age 15 or over.",
author = "E. Negri and {La Vecchia}, C. and F. Parazzini and R. Savoldelli and A. Gentile and B. D'Avanzo and A. Gramenzi and S. Franceschi",
year = "1989",
language = "English",
volume = "49",
pages = "7158--7161",
journal = "Journal of Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "24 I",

}

TY - JOUR

T1 - Reproductive and menstrual factors and risk of colorectal cancer

AU - Negri, E.

AU - La Vecchia, C.

AU - Parazzini, F.

AU - Savoldelli, R.

AU - Gentile, A.

AU - D'Avanzo, B.

AU - Gramenzi, A.

AU - Franceschi, S.

PY - 1989

Y1 - 1989

N2 - The relation between reproductive and menstrual factors and the risk of colorectal cancer was investigated in a case-control study conducted in Northern Italy on 279 women with colon cancer, 153 with rectal cancer and 386 controls admitted to hospital for a wide spectrum of acute, nonneoplastic, nondigestive disorders. Compared with nulliparous women, the relative risks (RR) of colon cancer were 1.1 for one and two births, 1.3 for three or four, and 1.1 for five or more. Corresponding values for rectal cancer were 0.9 for one, 1.1 for two, 1.4 for three or four, and 0.8 for five or more births. No significant association emerged with number of abortions, and no consistent pattern of trends for both colon and rectum cancer was observed in relation to age at first or last birth. Women whose menarche occurred at age 15 or over were at significantly lower risk of colon cancer (RR 0.5, 95% confidence interval = 0.3-0.9), and the point estimate was below unity, though nonsignificantly, for rectal cancer too (RR = 0.7). There was no relation between age at menopause, duration of menstrual cycles, and cancers of the colon and rectum. The present study produced no evidence that reproductive factors are related to colorectal cancer in this population. With this sample size, it was possible to exclude relative risks below 0.8 for colon and 0.7 for rectal cancer among multiparous women versus nulliparous ones. These findings are thus inconsistent with the epidemiological evidence on reproductive and menstrual factors and breast cancer in this and other populations, with the sole potential exception of the reduced risk of colorectal cancer among women whose menarche occurred at age 15 or over.

AB - The relation between reproductive and menstrual factors and the risk of colorectal cancer was investigated in a case-control study conducted in Northern Italy on 279 women with colon cancer, 153 with rectal cancer and 386 controls admitted to hospital for a wide spectrum of acute, nonneoplastic, nondigestive disorders. Compared with nulliparous women, the relative risks (RR) of colon cancer were 1.1 for one and two births, 1.3 for three or four, and 1.1 for five or more. Corresponding values for rectal cancer were 0.9 for one, 1.1 for two, 1.4 for three or four, and 0.8 for five or more births. No significant association emerged with number of abortions, and no consistent pattern of trends for both colon and rectum cancer was observed in relation to age at first or last birth. Women whose menarche occurred at age 15 or over were at significantly lower risk of colon cancer (RR 0.5, 95% confidence interval = 0.3-0.9), and the point estimate was below unity, though nonsignificantly, for rectal cancer too (RR = 0.7). There was no relation between age at menopause, duration of menstrual cycles, and cancers of the colon and rectum. The present study produced no evidence that reproductive factors are related to colorectal cancer in this population. With this sample size, it was possible to exclude relative risks below 0.8 for colon and 0.7 for rectal cancer among multiparous women versus nulliparous ones. These findings are thus inconsistent with the epidemiological evidence on reproductive and menstrual factors and breast cancer in this and other populations, with the sole potential exception of the reduced risk of colorectal cancer among women whose menarche occurred at age 15 or over.

UR - http://www.scopus.com/inward/record.url?scp=0024818012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024818012&partnerID=8YFLogxK

M3 - Article

VL - 49

SP - 7158

EP - 7161

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

IS - 24 I

ER -