Reproductive factors and clinical features of Parkinson's disease

Emanuele Cereda, Michela Barichella, Erica Cassani, Riccardo Caccialanza, Gianni Pezzoli

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Literature suggests that sex steroid hormones may modify the risk for Parkinson's disease (PD). We investigated the potential effect of reproductive factors on the clinical features of idiopathic PD (IPD) patients. Methods: All IPD female patients admitted to and evaluated at our Institute over a 12-month period were included in the present cross-sectional study. We investigated the effect of the following parameters by multivariate linear regression analysis: age at menarche, age at menopause, length of fertile life, duration of exposure to endogenous estrogens and cumulative length of pregnancies, use of contraceptives and hormonal replacement therapy. Results: In total, 579 patients were evaluated and 497 reported menopause before PD onset. In this population, age at PD onset was positively associated with age at menarche and at menopause, length of fertile life and duration of estrogen exposure. Moreover, UPDRS motor score was inversely associated with age at menopause, length of fertile life and duration of estrogen exposure. Increasing age at menarche was also associated with predominant resting tremor at PD onset. In models refitted on patients with early PD (disease duration

Original languageEnglish
Pages (from-to)1094-1099
Number of pages6
JournalParkinsonism and Related Disorders
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Parkinson Disease
Menopause
Menarche
Estrogens
Gonadal Steroid Hormones
Tremor
Contraceptive Agents
Linear Models
Cross-Sectional Studies
Regression Analysis
Pregnancy
Population
Therapeutics

Keywords

  • Clinical features
  • Estrogens
  • Parkinson's disease
  • Reproductive factors

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Reproductive factors and clinical features of Parkinson's disease. / Cereda, Emanuele; Barichella, Michela; Cassani, Erica; Caccialanza, Riccardo; Pezzoli, Gianni.

In: Parkinsonism and Related Disorders, Vol. 19, No. 12, 12.2013, p. 1094-1099.

Research output: Contribution to journalArticle

Cereda, Emanuele ; Barichella, Michela ; Cassani, Erica ; Caccialanza, Riccardo ; Pezzoli, Gianni. / Reproductive factors and clinical features of Parkinson's disease. In: Parkinsonism and Related Disorders. 2013 ; Vol. 19, No. 12. pp. 1094-1099.
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