Reproductive factors and risk of hormone receptor positive and negative breast cancer: A cohort study

Rebecca Ritte, Kaja Tikk, Annekatrin Lukanova, Anne Tjønneland, Anja Olsen, Kim Overvad, Laure Dossus, Agnès Fournier, Françoise Clavel-Chapelon, Verena Grote, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Franco Berrino, Amalia Mattiello, Rosario Tumino, Carlotta SacerdoteJosé R. Quirós, Genevieve Buckland, Esther Molina-Montes, María Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, H. B. Bueno-de-Mesquita, Carla H. van Gils, Petra H M Peeters, Nick Wareham, Kay Tee Khaw, Timothy J. Key, Ruth C. Travis, Elisabete Weiderpass, Vanessa Dumeaux, Eliv Lund, Malin Sund, Anne Andersson, Isabelle Romieu, Sabina Rinaldi, Paulo Vineis, Melissa A. Merritt, Elio Riboli, Rudolf Kaaks

Research output: Contribution to journalArticle

Abstract

Background: The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain.Methods: Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, number of children, age at first and last pregnancies, time since last full-term childbirth, breastfeeding, age at menopause, ever having an abortion and use of oral contraceptives [OC]) with risk of ER-PR- (n = 998) and ER+PR+ (n = 3,567) breast tumors.Results: A later first full-term childbirth was associated with increased risk of ER+PR+ tumors but not with risk of ER-PR- tumors (≥35 vs. ≤19 years HR: 1.47 [95% CI 1.15-1.88] ptrend <0.001 for ER+PR+ tumors; ≥35 vs. ≤19 years HR: 0.93 [95% CI 0.53-1.65] ptrend = 0.96 for ER-PR- tumors; Phet = 0.03). The risk associations of menarcheal age, and time period between menarche and first full-term childbirth with ER-PR-tumors were in the similar direction with risk of ER+PR+ tumors (phet = 0.50), although weaker in magnitude and statistically only borderline significant. Other parity related factors such as ever a full-term birth, number of births, age- and time since last birth were associated only with ER+PR+ malignancies, however no statistical heterogeneity between breast cancer subtypes was observed. Breastfeeding and OC use were generally not associated with breast cancer subtype risk.Conclusion: Our study provides possible evidence that age at menarche, and time between menarche and first full-term childbirth may be associated with the etiology of both HR-negative and HR-positive malignancies, although the associations with HR-negative breast cancer were only borderline significant.

Original languageEnglish
Article number584
JournalBMC Cancer
Volume13
DOIs
Publication statusPublished - Dec 9 2013

Fingerprint

Cohort Studies
Hormones
Breast Neoplasms
Menarche
Parturition
Neoplasms
Oral Contraceptives
Parity
Breast Feeding
Term Birth
Pregnancy
Age Factors
Menopause
Proportional Hazards Models

Keywords

  • Breast cancer
  • ER-receptor
  • Menopause
  • Oral contraceptive
  • Parity
  • PR-receptor
  • Reproductive factors
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Cite this

Ritte, R., Tikk, K., Lukanova, A., Tjønneland, A., Olsen, A., Overvad, K., ... Kaaks, R. (2013). Reproductive factors and risk of hormone receptor positive and negative breast cancer: A cohort study. BMC Cancer, 13, [584]. https://doi.org/10.1186/1471-2407-13-584

Reproductive factors and risk of hormone receptor positive and negative breast cancer : A cohort study. / Ritte, Rebecca; Tikk, Kaja; Lukanova, Annekatrin; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Dossus, Laure; Fournier, Agnès; Clavel-Chapelon, Françoise; Grote, Verena; Boeing, Heiner; Aleksandrova, Krasimira; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Berrino, Franco; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Quirós, José R.; Buckland, Genevieve; Molina-Montes, Esther; Chirlaque, María Dolores; Ardanaz, Eva; Amiano, Pilar; Bueno-de-Mesquita, H. B.; van Gils, Carla H.; Peeters, Petra H M; Wareham, Nick; Khaw, Kay Tee; Key, Timothy J.; Travis, Ruth C.; Weiderpass, Elisabete; Dumeaux, Vanessa; Lund, Eliv; Sund, Malin; Andersson, Anne; Romieu, Isabelle; Rinaldi, Sabina; Vineis, Paulo; Merritt, Melissa A.; Riboli, Elio; Kaaks, Rudolf.

In: BMC Cancer, Vol. 13, 584, 09.12.2013.

Research output: Contribution to journalArticle

Ritte, R, Tikk, K, Lukanova, A, Tjønneland, A, Olsen, A, Overvad, K, Dossus, L, Fournier, A, Clavel-Chapelon, F, Grote, V, Boeing, H, Aleksandrova, K, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Berrino, F, Mattiello, A, Tumino, R, Sacerdote, C, Quirós, JR, Buckland, G, Molina-Montes, E, Chirlaque, MD, Ardanaz, E, Amiano, P, Bueno-de-Mesquita, HB, van Gils, CH, Peeters, PHM, Wareham, N, Khaw, KT, Key, TJ, Travis, RC, Weiderpass, E, Dumeaux, V, Lund, E, Sund, M, Andersson, A, Romieu, I, Rinaldi, S, Vineis, P, Merritt, MA, Riboli, E & Kaaks, R 2013, 'Reproductive factors and risk of hormone receptor positive and negative breast cancer: A cohort study', BMC Cancer, vol. 13, 584. https://doi.org/10.1186/1471-2407-13-584
Ritte, Rebecca ; Tikk, Kaja ; Lukanova, Annekatrin ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Dossus, Laure ; Fournier, Agnès ; Clavel-Chapelon, Françoise ; Grote, Verena ; Boeing, Heiner ; Aleksandrova, Krasimira ; Trichopoulou, Antonia ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Palli, Domenico ; Berrino, Franco ; Mattiello, Amalia ; Tumino, Rosario ; Sacerdote, Carlotta ; Quirós, José R. ; Buckland, Genevieve ; Molina-Montes, Esther ; Chirlaque, María Dolores ; Ardanaz, Eva ; Amiano, Pilar ; Bueno-de-Mesquita, H. B. ; van Gils, Carla H. ; Peeters, Petra H M ; Wareham, Nick ; Khaw, Kay Tee ; Key, Timothy J. ; Travis, Ruth C. ; Weiderpass, Elisabete ; Dumeaux, Vanessa ; Lund, Eliv ; Sund, Malin ; Andersson, Anne ; Romieu, Isabelle ; Rinaldi, Sabina ; Vineis, Paulo ; Merritt, Melissa A. ; Riboli, Elio ; Kaaks, Rudolf. / Reproductive factors and risk of hormone receptor positive and negative breast cancer : A cohort study. In: BMC Cancer. 2013 ; Vol. 13.
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abstract = "Background: The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain.Methods: Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, number of children, age at first and last pregnancies, time since last full-term childbirth, breastfeeding, age at menopause, ever having an abortion and use of oral contraceptives [OC]) with risk of ER-PR- (n = 998) and ER+PR+ (n = 3,567) breast tumors.Results: A later first full-term childbirth was associated with increased risk of ER+PR+ tumors but not with risk of ER-PR- tumors (≥35 vs. ≤19 years HR: 1.47 [95{\%} CI 1.15-1.88] ptrend <0.001 for ER+PR+ tumors; ≥35 vs. ≤19 years HR: 0.93 [95{\%} CI 0.53-1.65] ptrend = 0.96 for ER-PR- tumors; Phet = 0.03). The risk associations of menarcheal age, and time period between menarche and first full-term childbirth with ER-PR-tumors were in the similar direction with risk of ER+PR+ tumors (phet = 0.50), although weaker in magnitude and statistically only borderline significant. Other parity related factors such as ever a full-term birth, number of births, age- and time since last birth were associated only with ER+PR+ malignancies, however no statistical heterogeneity between breast cancer subtypes was observed. Breastfeeding and OC use were generally not associated with breast cancer subtype risk.Conclusion: Our study provides possible evidence that age at menarche, and time between menarche and first full-term childbirth may be associated with the etiology of both HR-negative and HR-positive malignancies, although the associations with HR-negative breast cancer were only borderline significant.",
keywords = "Breast cancer, ER-receptor, Menopause, Oral contraceptive, Parity, PR-receptor, Reproductive factors, Risk factors",
author = "Rebecca Ritte and Kaja Tikk and Annekatrin Lukanova and Anne Tj{\o}nneland and Anja Olsen and Kim Overvad and Laure Dossus and Agn{\`e}s Fournier and Fran{\cc}oise Clavel-Chapelon and Verena Grote and Heiner Boeing and Krasimira Aleksandrova and Antonia Trichopoulou and Pagona Lagiou and Dimitrios Trichopoulos and Domenico Palli and Franco Berrino and Amalia Mattiello and Rosario Tumino and Carlotta Sacerdote and Quir{\'o}s, {Jos{\'e} R.} and Genevieve Buckland and Esther Molina-Montes and Chirlaque, {Mar{\'i}a Dolores} and Eva Ardanaz and Pilar Amiano and Bueno-de-Mesquita, {H. B.} and {van Gils}, {Carla H.} and Peeters, {Petra H M} and Nick Wareham and Khaw, {Kay Tee} and Key, {Timothy J.} and Travis, {Ruth C.} and Elisabete Weiderpass and Vanessa Dumeaux and Eliv Lund and Malin Sund and Anne Andersson and Isabelle Romieu and Sabina Rinaldi and Paulo Vineis and Merritt, {Melissa A.} and Elio Riboli and Rudolf Kaaks",
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TY - JOUR

T1 - Reproductive factors and risk of hormone receptor positive and negative breast cancer

T2 - A cohort study

AU - Ritte, Rebecca

AU - Tikk, Kaja

AU - Lukanova, Annekatrin

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Dossus, Laure

AU - Fournier, Agnès

AU - Clavel-Chapelon, Françoise

AU - Grote, Verena

AU - Boeing, Heiner

AU - Aleksandrova, Krasimira

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Berrino, Franco

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Quirós, José R.

AU - Buckland, Genevieve

AU - Molina-Montes, Esther

AU - Chirlaque, María Dolores

AU - Ardanaz, Eva

AU - Amiano, Pilar

AU - Bueno-de-Mesquita, H. B.

AU - van Gils, Carla H.

AU - Peeters, Petra H M

AU - Wareham, Nick

AU - Khaw, Kay Tee

AU - Key, Timothy J.

AU - Travis, Ruth C.

AU - Weiderpass, Elisabete

AU - Dumeaux, Vanessa

AU - Lund, Eliv

AU - Sund, Malin

AU - Andersson, Anne

AU - Romieu, Isabelle

AU - Rinaldi, Sabina

AU - Vineis, Paulo

AU - Merritt, Melissa A.

AU - Riboli, Elio

AU - Kaaks, Rudolf

PY - 2013/12/9

Y1 - 2013/12/9

N2 - Background: The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain.Methods: Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, number of children, age at first and last pregnancies, time since last full-term childbirth, breastfeeding, age at menopause, ever having an abortion and use of oral contraceptives [OC]) with risk of ER-PR- (n = 998) and ER+PR+ (n = 3,567) breast tumors.Results: A later first full-term childbirth was associated with increased risk of ER+PR+ tumors but not with risk of ER-PR- tumors (≥35 vs. ≤19 years HR: 1.47 [95% CI 1.15-1.88] ptrend <0.001 for ER+PR+ tumors; ≥35 vs. ≤19 years HR: 0.93 [95% CI 0.53-1.65] ptrend = 0.96 for ER-PR- tumors; Phet = 0.03). The risk associations of menarcheal age, and time period between menarche and first full-term childbirth with ER-PR-tumors were in the similar direction with risk of ER+PR+ tumors (phet = 0.50), although weaker in magnitude and statistically only borderline significant. Other parity related factors such as ever a full-term birth, number of births, age- and time since last birth were associated only with ER+PR+ malignancies, however no statistical heterogeneity between breast cancer subtypes was observed. Breastfeeding and OC use were generally not associated with breast cancer subtype risk.Conclusion: Our study provides possible evidence that age at menarche, and time between menarche and first full-term childbirth may be associated with the etiology of both HR-negative and HR-positive malignancies, although the associations with HR-negative breast cancer were only borderline significant.

AB - Background: The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain.Methods: Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, number of children, age at first and last pregnancies, time since last full-term childbirth, breastfeeding, age at menopause, ever having an abortion and use of oral contraceptives [OC]) with risk of ER-PR- (n = 998) and ER+PR+ (n = 3,567) breast tumors.Results: A later first full-term childbirth was associated with increased risk of ER+PR+ tumors but not with risk of ER-PR- tumors (≥35 vs. ≤19 years HR: 1.47 [95% CI 1.15-1.88] ptrend <0.001 for ER+PR+ tumors; ≥35 vs. ≤19 years HR: 0.93 [95% CI 0.53-1.65] ptrend = 0.96 for ER-PR- tumors; Phet = 0.03). The risk associations of menarcheal age, and time period between menarche and first full-term childbirth with ER-PR-tumors were in the similar direction with risk of ER+PR+ tumors (phet = 0.50), although weaker in magnitude and statistically only borderline significant. Other parity related factors such as ever a full-term birth, number of births, age- and time since last birth were associated only with ER+PR+ malignancies, however no statistical heterogeneity between breast cancer subtypes was observed. Breastfeeding and OC use were generally not associated with breast cancer subtype risk.Conclusion: Our study provides possible evidence that age at menarche, and time between menarche and first full-term childbirth may be associated with the etiology of both HR-negative and HR-positive malignancies, although the associations with HR-negative breast cancer were only borderline significant.

KW - Breast cancer

KW - ER-receptor

KW - Menopause

KW - Oral contraceptive

KW - Parity

KW - PR-receptor

KW - Reproductive factors

KW - Risk factors

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