Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women from the European Prospective Investigation into Cancer and Nutrition

Laura Costas, Leila Lujan-Barroso, Yolanda Benavente, Naomi E. Allen, Pilar Amiano, Eva Ardanaz, Caroline Besson, Heiner Boeing, Bas Bueno-De-Mesquita, Iris Cervenka, Renée T. Fortner, Agnès Fournier, Marc Gunter, Sophia Harlid, José María Huerta, Mats Jerkeman, Karin Jirström, Rudolf Kaaks, Anna Karakatsani, Kay Tee KhawAnastasia Kotanidou, Eiliv Lund, Giovanna Masala, Amalia Mattiello, Beatrice Melin, Virginia Menéndez, Neil Murphy, Alexandra Nieters, Kim Overvad, Elio Riboli, Carlotta Sacerdote, Maria Jose Sánchez, Julie A. Schmidt, Sabina Sieri, Anne Tjønneland, Antonia Trichopoulou, Rosario Tumino, Roel Vermeulen, Elisabete Weiderpass, Silvia De Sanjosé, Antonio Agudo, Delphine Casabonne

Research output: Contribution to journalArticle

Abstract

The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.

Original languageEnglish
Pages (from-to)274-281
Number of pages8
JournalAmerican Journal of Epidemiology
Volume188
Issue number2
DOIs
Publication statusPublished - Feb 1 2019

Keywords

  • cohort studies
  • hormone therapy
  • hysterectomy
  • lymphoma
  • menopause
  • menstrual factors
  • oophorectomy
  • parity

ASJC Scopus subject areas

  • Epidemiology

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    Costas, L., Lujan-Barroso, L., Benavente, Y., Allen, N. E., Amiano, P., Ardanaz, E., Besson, C., Boeing, H., Bueno-De-Mesquita, B., Cervenka, I., Fortner, R. T., Fournier, A., Gunter, M., Harlid, S., Huerta, J. M., Jerkeman, M., Jirström, K., Kaaks, R., Karakatsani, A., ... Casabonne, D. (2019). Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women from the European Prospective Investigation into Cancer and Nutrition. American Journal of Epidemiology, 188(2), 274-281. https://doi.org/10.1093/aje/kwy259