Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity

Alessandra Longhi, Eleonora Porcu, Simone Petracchi, Michela Versari, Lucia Conticini, Gaetano Bacci

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

BACKGROUND. The side effects of chemotherapy on ovarian and reproductive functions in female patients who received adjuvant and/or neoadjuvant treatment for localized osteosarcoma of the extremities at our institution in the last 21 years (1974-1995) were assessed. METHODS. Ninety-two patients with a mean actual age of 26 (14-51) were interviewed. They had been followed 3 to 16 years after treatment (mean: 9.6 yrs). Twenty-four of them had received chemotherapy before puberty and 68 after puberty. RESULTS. Amenorrhea during chemotherapy occurred in 69% of postpuberal patients but only in 2 patients aged 39 and 43, respectively, was permanent. After the end of treatment, the patients' menstrual activity started again, and only a slight number of cases showed increases of menstrual irregularities. Twenty-two patients married after treatment; 20 patients started a pregnancy at a mean age of 27. Of these 20 patients, 3 had voluntary abortions and 17 succeeded. At the time of article submission, three were pregnant, 14 had 19 full term pregnancies, and no birth defects nor congenital anomalies were registered in their 19 full term newborns. CONCLUSIONS. In this group of female patients, chemotherapy seemed to alter neither their reproductive function nor the health of their newborns. (C) 2000 American Cancer Society.

Original languageEnglish
Pages (from-to)1961-1965
Number of pages5
JournalCancer
Volume89
Issue number9
DOIs
Publication statusPublished - Nov 1 2000

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Osteosarcoma
Adjuvant Chemotherapy
Extremities
Drug Therapy
Puberty
Pregnancy
Neoadjuvant Therapy
Amenorrhea
Therapeutics
Newborn Infant

Keywords

  • Chemotherapy-induced sterility
  • Congenital anomalies
  • Osteosarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. / Longhi, Alessandra; Porcu, Eleonora; Petracchi, Simone; Versari, Michela; Conticini, Lucia; Bacci, Gaetano.

In: Cancer, Vol. 89, No. 9, 01.11.2000, p. 1961-1965.

Research output: Contribution to journalArticle

Longhi, Alessandra ; Porcu, Eleonora ; Petracchi, Simone ; Versari, Michela ; Conticini, Lucia ; Bacci, Gaetano. / Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. In: Cancer. 2000 ; Vol. 89, No. 9. pp. 1961-1965.
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