Reproductive life events and Alzheimer's disease in Italian women: A retrospective study

Chiara Zucchella, Elena Sinforiani, Antonietta Citterio, Valentina Giarracca, Giorgio Bono, Marco Mauri

Research output: Contribution to journalArticlepeer-review


The aim of our study was to understand the complex relationship between the major reproductive life events in women with Alzheimer's disease. In a retrospective, case-control study, 275 women with Alzheimer's disease (AD) and 276 control patients from a hospital population were enrolled from July 2007 to December 2010. The AD patients presented with later menopause (P <0.01), lower occurrence of surgical menopause (P <0.04), reduced hormone-replacement therapy intake (P <0.0001), and a longer reproductive life span (P <0.01), compared to controls. No significant differences were found with respect to age at puberty, number of pregnancies, previous abortions, or contraceptive therapy. A higher education level appeared to have a protective role against the risk of developing AD. In women, menopause and hormone-replacement therapy can differentially modulate the clinical manifestations of AD, but these factors do not play a predictive role in its development.

Original languageEnglish
Pages (from-to)555-560
Number of pages6
JournalNeuropsychiatric Disease and Treatment
Publication statusPublished - Nov 20 2012


  • Alzheimer's disease
  • Education
  • Gender
  • Hormone-replacement therapy
  • Menopause
  • Surgical menopause

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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