Reproductive, menstrual, and other hormone-related factors and risk of renal cell cancer

Antonella Zucchetto, Renato Talamini, Luigino Dal Maso, Eva Negri, Jerry Polesel, Valerio Ramazzotti, Maurizio Montella, Vincenzo Canzonieri, Diego Serraino, Carlo La Vecchia, Silvia Franceschi

Research output: Contribution to journalArticlepeer-review


A role of hormone-related factors in renal cell cancer (RCC) etiology has been hypothesized, but the epidemiological evidence is inconsistent. The present study aimed at evaluating the effect of reproductive, menstrual and other gender-specific variables on RCC risk among women. This study is part of a larger hospital-based, case-control study on RCC risk, conducted in northern, central and southern Italy. Cases were 273 women, below age 80, with histologically confirmed, incident RCC. Controls were 546 women hospitalized for acute, nonneoplastic conditions, frequency-matched to cases by age and center. Odds ratios (OR) and 95% confidence intervals (CI) were computed using multiple logistic regression models. RCC risk was inversely related to age at first birth (OR = 0.7, 95% CI 0.5-1.0, for ≥25 years vs.

Original languageEnglish
Pages (from-to)2213-2216
Number of pages4
JournalInternational Journal of Cancer
Issue number9
Publication statusPublished - Nov 1 2008


  • Case-control study
  • Hormones
  • Hysterectomy
  • Kidney cancer
  • Reproductive and menstrual factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)


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