Reproductive outcomes and fertility preservation strategies in women with malignant ovarian germ cell tumors after fertility sparing surgery.

Francesca Maria Vasta, Miriam Dellino, Alice Bergamini, Giulio Gargano, Angelo Paradiso, Vera Loizzi, Luca Bocciolone, Erica Silvestris, Micaela Petrone, Gennaro Cormio, Giorgia Mangili

Research output: Contribution to journalReview articlepeer-review

Abstract

Malignant ovarian germ cell tumors are rare tumors that mainly affect patients of reproductive age. The aim of this study was to investigate the reproductive outcomes and fertility preservation strategies in malignant ovarian germ cell tumors after fertility-sparing surgery. Data in literature support that fertility-sparing surgery is associated with an excellent oncological outcome not only in early stages malignant ovarian germ cell tumors but also in advanced stages. Moreover, the possibility of performing conservative treatment should be considered even in case of relapse or advanced disease, given the high chemosensitivity. Indeed, available data have shown that menstrual function is maintained after platinum-based regimens in over 85–95% of patients with malignant ovarian germ cell tumors and rate of premature menopause reported in literature ranges between 3% and 7.4%, while premature ovarian failure rates are between 3.4% and 5%. Moreover, reproductive outcomes are about 80% with no increase in the risk of teratogenicity compared to general population. Therefore, conservative surgery for malignant ovarian germ cell tumors currently may represent a therapeutic option in patients who wish to preserve fertility but must be available for extended follow-up and after subscribing to informed consent.

Original languageEnglish
Article number554
Pages (from-to)1-13
Number of pages13
JournalBiomedicines
Volume8
Issue number12
DOIs
Publication statusPublished - Nov 30 2020

Keywords

  • Fertility preservation
  • Fertility sparing surgery
  • Malignant germ cell ovarian tumors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'Reproductive outcomes and fertility preservation strategies in women with malignant ovarian germ cell tumors after fertility sparing surgery.'. Together they form a unique fingerprint.

Cite this