Reproductive Status Is Associated with the Severity of Fibrosis in Women with Hepatitis C

Erica Villa, Ranka Vukotic, Calogero Cammà, Salvatore Petta, Alfredo Di Leo, Stefano Gitto, Elena Turola, Aimilia Karampatou, Luisa Losi, Veronica Bernabucci, Annamaria Cenci, Simonetta Tagliavini, Enrica Baraldi, Nicola De Maria, Roberta Gelmini, Elena Bertolini, Maria Rendina, Antonio Francavilla

Research output: Contribution to journalArticlepeer-review


Introduction: Chronic hepatitis C is the main cause of death in patients with end-stage liver disease. Prognosis depends on the increase of fibrosis, whose progression is twice as rapid in men as in women. Aim of the study was to evaluate the effects of reproductive stage on fibrosis severity in women and to compare these findings with age-matched men. Materials and Methods: A retrospective study of 710 consecutive patients with biopsy-proven chronic hepatitis C was conducted, using data from a clinical database of two tertiary Italian care centers. Four age-matched groups of men served as controls. Data about demographics, biochemistry, liver biopsy and ultrasonography were analyzed. Contributing factors were assessed by multivariate logistic regression analysis. Results: Liver fibrosis was more advanced in the early menopausal than in the fully reproductive (P

Original languageEnglish
Article numbere44624
JournalPLoS One
Issue number9
Publication statusPublished - Jan 9 2013

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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