Reprogramming T-cells for adoptive immunotherapy of ovarian cancer

Sofia Genta, Eleonora Ghisoni, Gaia Giannone, Gloria Mittica, Giorgio Valabrega

Research output: Contribution to journalReview article

Abstract

Introduction: Epithelial ovarian cancer (EOC) is the most common cause of death among gynecological malignancies. Despite surgical and pharmacological efforts to improve patients’ outcome, persistent and recurrent EOC remains an un-eradicable disease. Chimeric associated antigens (CAR) T cells are T lymphocytes expressing an engineered T cell receptor that activate the immune response after an MHC unrestricted recognition of specific antigens, including tumor associated antigens (TAAs). CART cells have been shown to be effective in the treatment of hematologic tumors even if frequently associated with potentially severe toxicity and high production costs. Areas covered: In this review, we will focus on preclinical and clinical studies evaluating CART activity in EOC in order to identify possible difficulties and advantages of their use in this particular setting. Expert Opinion: The pattern of diffusion within the peritoneal cavity, the tumor microenvironment and the high rate of TAAs make EOC a particularly interesting model for CART cells use. Data from preclinical studies indicate a potential activity of CARTs in EOC, but robust clinical data are still awaited. Further studies are needed to determine the best methods of administration and the most effective CAR type to treat EOC patients.

Original languageEnglish
Pages (from-to)359-367
Number of pages9
JournalExpert Opinion on Biological Therapy
Volume18
Issue number4
DOIs
Publication statusPublished - Apr 3 2018

Keywords

  • Chimeric antigen receptor
  • immunotherapy
  • ovarian cancer
  • T cell

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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