Requirement for leptin in the induction and progression of autoimmune encephalomyelitis

Giuseppe Matarese, Antonio Di Giacomo, Veronica Sanna, Graham M. Lord, Jane K. Howard, Antonino Di Tuoro, Stephen R. Bloom, Robert I. Lechler, Serafino Zappacosta, Silvia Fontana

Research output: Contribution to journalArticle

265 Citations (Scopus)

Abstract

Recent evidence indicates that leptin modifies T cell immunity, and may provide a key link between nutritional deficiency and immune dysfunction. To study the influence of leptin on autoimmunity, susceptibility to experimental autoimmune encephalomyelitis induced by immunization with a myelin-derived peptide was examined in leptin-deficient, C57BL/6J-ob/ob mice, with or without leptin replacement, and in wild-type controls. Leptin replacement converted disease resistance to susceptibility in the C57BL/6J-ob/ob mice; this was accompanied by a switch from a Th2 to Th1 pattern of cytokine release and consequent reversal of Ig subclass production. Our findings suggest that leptin is required for the induction and maintenance of an effective proinflammatory immune response in the CNS.

Original languageEnglish
Pages (from-to)5909-5916
Number of pages8
JournalJournal of Immunology
Volume166
Issue number10
Publication statusPublished - May 15 2001

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Encephalomyelitis
Leptin
Disease Resistance
Autoimmune Experimental Encephalomyelitis
Myelin Sheath
Autoimmunity
Malnutrition
Immunity
Immunization
Cytokines
T-Lymphocytes
Peptides

ASJC Scopus subject areas

  • Immunology

Cite this

Matarese, G., Di Giacomo, A., Sanna, V., Lord, G. M., Howard, J. K., Di Tuoro, A., ... Fontana, S. (2001). Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. Journal of Immunology, 166(10), 5909-5916.

Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. / Matarese, Giuseppe; Di Giacomo, Antonio; Sanna, Veronica; Lord, Graham M.; Howard, Jane K.; Di Tuoro, Antonino; Bloom, Stephen R.; Lechler, Robert I.; Zappacosta, Serafino; Fontana, Silvia.

In: Journal of Immunology, Vol. 166, No. 10, 15.05.2001, p. 5909-5916.

Research output: Contribution to journalArticle

Matarese, G, Di Giacomo, A, Sanna, V, Lord, GM, Howard, JK, Di Tuoro, A, Bloom, SR, Lechler, RI, Zappacosta, S & Fontana, S 2001, 'Requirement for leptin in the induction and progression of autoimmune encephalomyelitis', Journal of Immunology, vol. 166, no. 10, pp. 5909-5916.
Matarese G, Di Giacomo A, Sanna V, Lord GM, Howard JK, Di Tuoro A et al. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. Journal of Immunology. 2001 May 15;166(10):5909-5916.
Matarese, Giuseppe ; Di Giacomo, Antonio ; Sanna, Veronica ; Lord, Graham M. ; Howard, Jane K. ; Di Tuoro, Antonino ; Bloom, Stephen R. ; Lechler, Robert I. ; Zappacosta, Serafino ; Fontana, Silvia. / Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. In: Journal of Immunology. 2001 ; Vol. 166, No. 10. pp. 5909-5916.
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