Requirements for the identification of dense-core granules

Jacopo Meldolesi, Evelina Chieregatti, Maria Luisa Malosio

Research output: Contribution to journalArticlepeer-review


Dense-core granules (DCGs), cytoplasmic organelles competent for regulated exocytosis, show considerable heterogeneity depending upon the specificity of their expressing cells - primarily neurons and neurosecretory cells. DCGs have been mainly identified by detecting their cargo molecules, often members of the granin family, and using conventional electron microscopy and immunocytochemistry. However, by a critical analysis of the various stages of DCG 'life' within neurosecretory cells, we have highlighted several specific molecular and functional properties that are common to all these organelles. We propose that these properties be considered as strict requirements for the identification of DCGs.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalTrends in Cell Biology
Issue number1
Publication statusPublished - Jan 2004

ASJC Scopus subject areas

  • Cell Biology


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