Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

Francesca Liuzzi, Claudia Fanelli, Maria Rosa Ciriolo, Claudia Cerella, Maria D'Alessio, Milena Denicola, Andrea Magrini, Antonio Bergamaschi, Lina Ghibelli

Research output: Contribution to journalArticlepeer-review

Abstract

Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.

Original languageEnglish
Pages (from-to)441-445
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1010
DOIs
Publication statusPublished - 2003

Keywords

  • Antioxidants
  • Apoptosis
  • Glutathione

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Fingerprint Dive into the research topics of 'Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion'. Together they form a unique fingerprint.

Cite this