Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion

Francesca Liuzzi, Claudia Fanelli, Maria Rosa Ciriolo, Claudia Cerella, Maria D'Alessio, Milena Denicola, Andrea Magrini, Antonio Bergamaschi, Lina Ghibelli

Research output: Contribution to journalArticle

Abstract

Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO2, 95% N2)-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.

Original languageEnglish
Pages (from-to)441-445
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1010
DOIs
Publication statusPublished - 2003

Fingerprint

Extrusion
Antioxidants
Apoptosis
U937 Cells
Free Radical Scavengers
Reducing Agents
Sulfhydryl Compounds
Oxidation
Rescue
Cells
Pathway
Trigger
Damage

Keywords

  • Antioxidants
  • Apoptosis
  • Glutathione

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion. / Liuzzi, Francesca; Fanelli, Claudia; Ciriolo, Maria Rosa; Cerella, Claudia; D'Alessio, Maria; Denicola, Milena; Magrini, Andrea; Bergamaschi, Antonio; Ghibelli, Lina.

In: Annals of the New York Academy of Sciences, Vol. 1010, 2003, p. 441-445.

Research output: Contribution to journalArticle

Liuzzi, F, Fanelli, C, Ciriolo, MR, Cerella, C, D'Alessio, M, Denicola, M, Magrini, A, Bergamaschi, A & Ghibelli, L 2003, 'Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion', Annals of the New York Academy of Sciences, vol. 1010, pp. 441-445. https://doi.org/10.1196/annals.1299.080
Liuzzi, Francesca ; Fanelli, Claudia ; Ciriolo, Maria Rosa ; Cerella, Claudia ; D'Alessio, Maria ; Denicola, Milena ; Magrini, Andrea ; Bergamaschi, Antonio ; Ghibelli, Lina. / Rescue of Cells from Apoptosis by Antioxidants Occurs Downstream from GSH Extrusion. In: Annals of the New York Academy of Sciences. 2003 ; Vol. 1010. pp. 441-445.
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