Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection

Veronica Bordoni, Eleonora Lalle, Francesca Colavita, Andrea Baiocchini, Roberta Nardacci, Laura Falasca, Fabrizio Carletti, Eleonora Cimini, Licia Bordi, Gary Kobinger, Valentina D'Ambrosio, Fabio Natale, Antonella Giancotti, Lucia Manganaro, Franca Del Nonno, Alimuddin Zumla, Giuseppina Liuzzi, Giuseppe Ippolito, Maria Rosaria Capobianchi, Chiara AgratiConcetta Castilletti

Research output: Contribution to journalArticlepeer-review

Abstract

The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.

Original languageEnglish
Article numberofz342
Pages (from-to)1-4
Number of pages4
JournalOpen Forum Infectious Diseases
Volume6
Issue number10
DOIs
Publication statusPublished - Oct 2019

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