TY - JOUR
T1 - Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection
AU - Bordoni, Veronica
AU - Lalle, Eleonora
AU - Colavita, Francesca
AU - Baiocchini, Andrea
AU - Nardacci, Roberta
AU - Falasca, Laura
AU - Carletti, Fabrizio
AU - Cimini, Eleonora
AU - Bordi, Licia
AU - Kobinger, Gary
AU - D'Ambrosio, Valentina
AU - Natale, Fabio
AU - Giancotti, Antonella
AU - Manganaro, Lucia
AU - Del Nonno, Franca
AU - Zumla, Alimuddin
AU - Liuzzi, Giuseppina
AU - Ippolito, Giuseppe
AU - Capobianchi, Maria Rosaria
AU - Agrati, Chiara
AU - Castilletti, Concetta
N1 - © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2019/10
Y1 - 2019/10
N2 - The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.
AB - The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.
U2 - 10.1093/ofid/ofz342
DO - 10.1093/ofid/ofz342
M3 - Article
C2 - 31660333
VL - 6
SP - 1
EP - 4
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 10
M1 - ofz342
ER -