Some cell mediated immunity tests (skin tests with varidase, candidine, mumps antigen, DNCB, lymphocyte PHA blastogenesis) were carried out in 50 children suffering from ALL, to establish if there might be some correlation between immunocompetence and the course of the disease and to evaluate the influence of chemotherapy on immunocompetence. Mumps antigen, candidine and varidase skin tests, which represent a secondary cell mediated response, proved similar at the onset of the disease and in remission. By contrast, the DNCB test, which is a primary cell mediated response, was found positive in 54.5% of the patients at the onset, and in only 25% in remission. In the latter cases the most strikingly positive responses were those obtained in children whose tests had turned out negative at the onset. This might suggest an anamnestic response. According to these results, chemotherapy seems to inhibit primary cell mediated responses: on the contrary, if the cell mediated reaction is induced before the use of chemotherapy, no immunosuppression takes place. PHA lymphocyte blastogenesis always turned out normal.
|Translated title of the contribution||Researches on delayed hypersensitivity in children with acute lymphoblastic leukemia (ALL). Appraisal of skin tests|
|Number of pages||6|
|Publication status||Published - 1976|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health