Resektion von lungenmetastasen. Langzeitresultate prognostischer faktoren auf der basis von 5206 fallen - The International Registry of Lung Metastases

Translated title of the contribution: Resection of lung metastases: Long-term results and prognostic analysis based on 5206 cases - The International Registry of Lung Metastases

G. Friedel, U. Pastorino, M. Buyse, R. J. Ginsberg, P. Girard, P. Goldstraw, M. Johnston, P. McCormack, H. Pass, J. B. Putnam, H. Toomes

Research output: Contribution to journalArticlepeer-review

Abstract

The International Registry of Lung Metastases was established in 1991 to asses the long-term results of pulmonary metastasectomy. The Registry has accrued 5206 cases of lung metastasectomy, from 18 departments of thoracic surgery in Europe (n = 13), USA (n = 4) and Canada (n = 1). Of these patients 4572 (88%) underwent complete surgical resection. The primary tumor was epithelial in 2260 (43%), sarcoma in 2173 (42%), germ cell in 363 (7%), and melanoma in 328 (6%) patients. The disease-free interval was 0 to 11 months in 1729 (33%) cases, 12 to 35 months in 1857 (36%) and more than 36 months in 1620 (31%). Single metastases accounted for 2383 (46%) cases and multiple lesions for 2726 (52%). Mean follow up was 46 months. Analysis was performed by Kaplan-Meier estimates of survival, relative risk of death and multivariate Cox model. The actuarial survival after complete metastasectomy was 36% at 5 years, 26% at 10 years and 22% at 15 years (median 35 months); the corresponding values for incomplete resection were 13% at 5 years and 7% at 10 years (median 15 months). Among complete resections, the 5-year survival was 33% for patients with a disease free-interval of 0 to 11 months and 45% for those with a disease-free interval of more than 36 months; 43% for single lesions and 27 for four or more lesions. Multivariate analysis showed a better prognosis for patients with germ cell tumors, disease-free interval of 36 months and more and single metastases. These results confirm that lung metastasectomy is a safe and potentially curative procedure.

Translated title of the contributionResection of lung metastases: Long-term results and prognostic analysis based on 5206 cases - The International Registry of Lung Metastases
Original languageGerman
Pages (from-to)96-103
Number of pages8
JournalZentralblatt fur Chirurgie
Volume124
Issue number2
Publication statusPublished - 1999

Keywords

  • Long-term survival
  • Lung metastasectomy
  • Lung metastases
  • Prognostic factors

ASJC Scopus subject areas

  • Surgery

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