Resident skin cells in psoriasis: a special look at the pathogenetic functions of keratinocytes

Cristina Albanesi, Ornella De Pità, Giampiero Girolomoni

Research output: Contribution to journalArticle

Abstract

Psoriasis is a chronic inflammatory skin disease characterized by exaggerated keratinocyte proliferation. Current paradigm indicates that psoriasis is driven by T cell-mediated immune responses targeting keratinocytes. However, psoriasis cannot be explained solely on the basis of T-cell activation, and it is likely that intrinsic alterations in epidermal keratinocytes play a very relevant role in disease expression. In particular, keratinocytes may be important in initiating, sustaining, and amplifying the inflammatory responses by expressing molecules involved in T-cell recruitment, retention, and activation. Keratinocytes are also a relevant source of growth factors for angiogenesis. Finally, intrinsic defects in cytokine and growth factor signaling in keratinocytes may be responsible for their aberrant hyperproliferation and differentiation to T cell-derived signals. Other skin resident cells such as fibroblasts, mast cells, and endothelial cells also contribute to psoriasis pathogenesis by expressing molecules involved in T-cell recruitment and activation.

Original languageEnglish
Pages (from-to)581-588
Number of pages8
JournalClinics in Dermatology
Volume25
Issue number6
DOIs
Publication statusPublished - Nov 2007

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ASJC Scopus subject areas

  • Dermatology

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