Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study

Elaine Fuertes, Iana Markevych, Deborah Jarvis, Danielle Vienneau, Kees de Hoogh, Josep Maria Antó, Gayan Bowatte, Roberto Bono, Angelo G. Corsico, Margareta Emtner, Thorarinn Gislason, José Antonio Gullón, Joachim Heinrich, John Henderson, Mathias Holm, Ane Johannessen, Bénédicte Leynaert, Alessandro Marcon, Pierpaolo Marchetti, Jesús Martínez MoratallaSilvia Pascual, Nicole Probst-Hensch, José Luis Sánchez-Ramos, Valerie Siroux, Johan Sommar, Joost Weyler, Nino Kuenzli, Bénédicte Jacquemin, Judith Garcia-Aymerich

Research output: Contribution to journalArticle

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Abstract

Background: Very few studies have examined whether a long-term beneficial effect of physical activity on lung function can be influenced by living in polluted urban areas. Objective: We assessed whether annual average residential concentrations of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters < 2.5 μm (PM2.5) and <10 μm (PM10) modify the effect of physical activity on lung function among never- (N = 2801) and current (N = 1719) smokers in the multi-center European Community Respiratory Health Survey. Methods: Associations between repeated assessments (at 27–57 and 39–67 years) of being physically active (physical activity: ≥2 times and ≥1 h per week) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were evaluated using adjusted mixed linear regression models. Models were conducted separately for never- and current smokers and stratified by residential long-term NO2, PM2.5 mass and PM10 mass concentrations (≤75th percentile (low/medium) versus >75th percentile (high)). Results: Among current smokers, physical activity and lung function were positively associated regardless of air pollution levels. Among never-smokers, physical activity was associated with lung function in areas with low/medium NO2, PM2.5 mass and PM10 mass concentrations (e.g. mean difference in FVC between active and non-active subjects was 43.0 mL (13.6, 72.5), 49.5 mL (20.1, 78.8) and 49.7 mL (18.6, 80.7), respectively), but these associations were attenuated in high air pollution areas. Only the interaction term of physical activity and PM10 mass for FEV1 among never-smokers was significant (p-value = 0.03). Conclusions: Physical activity has beneficial effects on adult lung function in current smokers, irrespective of residential air pollution levels in Western Europe. Trends among never-smokers living in high air pollution areas are less clear.

Original languageEnglish
Pages (from-to)364-372
Number of pages9
JournalEnvironment International
Volume120
DOIs
Publication statusPublished - Nov 1 2018

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physical activity
atmospheric pollution
nitrogen dioxide
aerodynamics
particulate matter
urban area

Keywords

  • Air pollution
  • Cohort
  • Lung function
  • Physical activity
  • Smoking

ASJC Scopus subject areas

  • Environmental Science(all)

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Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study. / Fuertes, Elaine; Markevych, Iana; Jarvis, Deborah; Vienneau, Danielle; de Hoogh, Kees; Antó, Josep Maria; Bowatte, Gayan; Bono, Roberto; Corsico, Angelo G.; Emtner, Margareta; Gislason, Thorarinn; Gullón, José Antonio; Heinrich, Joachim; Henderson, John; Holm, Mathias; Johannessen, Ane; Leynaert, Bénédicte; Marcon, Alessandro; Marchetti, Pierpaolo; Moratalla, Jesús Martínez; Pascual, Silvia; Probst-Hensch, Nicole; Sánchez-Ramos, José Luis; Siroux, Valerie; Sommar, Johan; Weyler, Joost; Kuenzli, Nino; Jacquemin, Bénédicte; Garcia-Aymerich, Judith.

In: Environment International, Vol. 120, 01.11.2018, p. 364-372.

Research output: Contribution to journalArticle

Fuertes, E, Markevych, I, Jarvis, D, Vienneau, D, de Hoogh, K, Antó, JM, Bowatte, G, Bono, R, Corsico, AG, Emtner, M, Gislason, T, Gullón, JA, Heinrich, J, Henderson, J, Holm, M, Johannessen, A, Leynaert, B, Marcon, A, Marchetti, P, Moratalla, JM, Pascual, S, Probst-Hensch, N, Sánchez-Ramos, JL, Siroux, V, Sommar, J, Weyler, J, Kuenzli, N, Jacquemin, B & Garcia-Aymerich, J 2018, 'Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study', Environment International, vol. 120, pp. 364-372. https://doi.org/10.1016/j.envint.2018.07.032
Fuertes, Elaine ; Markevych, Iana ; Jarvis, Deborah ; Vienneau, Danielle ; de Hoogh, Kees ; Antó, Josep Maria ; Bowatte, Gayan ; Bono, Roberto ; Corsico, Angelo G. ; Emtner, Margareta ; Gislason, Thorarinn ; Gullón, José Antonio ; Heinrich, Joachim ; Henderson, John ; Holm, Mathias ; Johannessen, Ane ; Leynaert, Bénédicte ; Marcon, Alessandro ; Marchetti, Pierpaolo ; Moratalla, Jesús Martínez ; Pascual, Silvia ; Probst-Hensch, Nicole ; Sánchez-Ramos, José Luis ; Siroux, Valerie ; Sommar, Johan ; Weyler, Joost ; Kuenzli, Nino ; Jacquemin, Bénédicte ; Garcia-Aymerich, Judith. / Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study. In: Environment International. 2018 ; Vol. 120. pp. 364-372.
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T1 - Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study

AU - Fuertes, Elaine

AU - Markevych, Iana

AU - Jarvis, Deborah

AU - Vienneau, Danielle

AU - de Hoogh, Kees

AU - Antó, Josep Maria

AU - Bowatte, Gayan

AU - Bono, Roberto

AU - Corsico, Angelo G.

AU - Emtner, Margareta

AU - Gislason, Thorarinn

AU - Gullón, José Antonio

AU - Heinrich, Joachim

AU - Henderson, John

AU - Holm, Mathias

AU - Johannessen, Ane

AU - Leynaert, Bénédicte

AU - Marcon, Alessandro

AU - Marchetti, Pierpaolo

AU - Moratalla, Jesús Martínez

AU - Pascual, Silvia

AU - Probst-Hensch, Nicole

AU - Sánchez-Ramos, José Luis

AU - Siroux, Valerie

AU - Sommar, Johan

AU - Weyler, Joost

AU - Kuenzli, Nino

AU - Jacquemin, Bénédicte

AU - Garcia-Aymerich, Judith

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background: Very few studies have examined whether a long-term beneficial effect of physical activity on lung function can be influenced by living in polluted urban areas. Objective: We assessed whether annual average residential concentrations of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters < 2.5 μm (PM2.5) and <10 μm (PM10) modify the effect of physical activity on lung function among never- (N = 2801) and current (N = 1719) smokers in the multi-center European Community Respiratory Health Survey. Methods: Associations between repeated assessments (at 27–57 and 39–67 years) of being physically active (physical activity: ≥2 times and ≥1 h per week) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were evaluated using adjusted mixed linear regression models. Models were conducted separately for never- and current smokers and stratified by residential long-term NO2, PM2.5 mass and PM10 mass concentrations (≤75th percentile (low/medium) versus >75th percentile (high)). Results: Among current smokers, physical activity and lung function were positively associated regardless of air pollution levels. Among never-smokers, physical activity was associated with lung function in areas with low/medium NO2, PM2.5 mass and PM10 mass concentrations (e.g. mean difference in FVC between active and non-active subjects was 43.0 mL (13.6, 72.5), 49.5 mL (20.1, 78.8) and 49.7 mL (18.6, 80.7), respectively), but these associations were attenuated in high air pollution areas. Only the interaction term of physical activity and PM10 mass for FEV1 among never-smokers was significant (p-value = 0.03). Conclusions: Physical activity has beneficial effects on adult lung function in current smokers, irrespective of residential air pollution levels in Western Europe. Trends among never-smokers living in high air pollution areas are less clear.

AB - Background: Very few studies have examined whether a long-term beneficial effect of physical activity on lung function can be influenced by living in polluted urban areas. Objective: We assessed whether annual average residential concentrations of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters < 2.5 μm (PM2.5) and <10 μm (PM10) modify the effect of physical activity on lung function among never- (N = 2801) and current (N = 1719) smokers in the multi-center European Community Respiratory Health Survey. Methods: Associations between repeated assessments (at 27–57 and 39–67 years) of being physically active (physical activity: ≥2 times and ≥1 h per week) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were evaluated using adjusted mixed linear regression models. Models were conducted separately for never- and current smokers and stratified by residential long-term NO2, PM2.5 mass and PM10 mass concentrations (≤75th percentile (low/medium) versus >75th percentile (high)). Results: Among current smokers, physical activity and lung function were positively associated regardless of air pollution levels. Among never-smokers, physical activity was associated with lung function in areas with low/medium NO2, PM2.5 mass and PM10 mass concentrations (e.g. mean difference in FVC between active and non-active subjects was 43.0 mL (13.6, 72.5), 49.5 mL (20.1, 78.8) and 49.7 mL (18.6, 80.7), respectively), but these associations were attenuated in high air pollution areas. Only the interaction term of physical activity and PM10 mass for FEV1 among never-smokers was significant (p-value = 0.03). Conclusions: Physical activity has beneficial effects on adult lung function in current smokers, irrespective of residential air pollution levels in Western Europe. Trends among never-smokers living in high air pollution areas are less clear.

KW - Air pollution

KW - Cohort

KW - Lung function

KW - Physical activity

KW - Smoking

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