Residential proximity to major roadways and lung cancer mortality. Italy, 1990–2010: An observational study

Ettore Bidoli, Marilena Pappagallo, Silvia Birri, Luisa Frova, Loris Zanier, Diego Serraino

Research output: Contribution to journalArticlepeer-review


Background: Air pollution from road traffic has been associated to an increased risk of lung cancer. Herein, we investigated the association between lung cancer mortality and residence near Italian highways or national major roads. Methods: Information on deaths for lung cancer registered from 1990 to 2010 and stratified by age, gender, and urban or rural municipality of residence at death were obtained from the National Institute of Statistics. Distance between the centroid of the municipality of residence and closest major roadways was considered as a proxy of pollution exposure. Relative Risks (RR) and 95% confidence intervals (CI) were computed using Poisson log-linear models adjusted for age, calendar period, deprivation index, North/South gradient, and urban/rural status. Results: A gradient in risk for lung cancer mortality was seen for residents within 50 meters (m) of national major roads. In particular, in rural municipalities a statistically significant increased risk for lung cancer death was observed in both sexes (RR = 1.27 for distance

Original languageEnglish
Article number191
JournalInternational Journal of Environmental Research and Public Health
Issue number2
Publication statusPublished - Feb 3 2016


  • Italy
  • Lung cancer
  • Major roadways
  • Mortality
  • Nationwide
  • Residence proximity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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