Residual beta cell function and spontaneous clinical remission in type 1 diabetes mellitus: The role of puberty

R. Bonfanti, E. Bognetti, F. Meschi, A. Brunelli, M. C. Riva, M. R. Pastore, G. Calori, G. Chiumello

Research output: Contribution to journalArticlepeer-review


To investigate the role of puberty on spontaneous clinical remission and on secretion of residual C-peptide during the first year of type 1 diabetes mellitus, we studied 77 pre-pubertal, 39 pubertal and 41 post-pubertal type 1 diabetic patients. Spontaneous partial clinical remission (HbA(1c) within the normal range and insulin dose less than 0.3 U·kg-1 body weight·day-1 lasting for at least 10 days) decreased with duration of diabetes: months 3 vs 6 vs 12, respectively 13 vs 7 vs 4% (P <0.025). Remission was higher in post-pubertal than pubertal and prepubertal patients: month 6 respectively 20 vs 5 vs 1% (P <0.001). Secretion of C-peptide was significantly lower in pre-pubertal than the other two groups of patients. Basal and stimulated C-peptide secretion were higher in patients in clinical remission than in those who were not: basal value 0.4 (0.26-0.53) vs 0.28 (0.14-0.4) nmol/l (P <0.05); stimulated value 0.63 (0.5-0.95) vs 0.56 (0.31-0.74) nmol/l (P <0.05). Spontaneous remission is less frequent in children and adolescent patients than in adult post-pubertal patients, but different mechanisms may be involved. Low residual insulin secretion seems implicated in children meanwhile low insulin sensitivity could be more important in pubertal patients.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalActa Diabetologica
Issue number2
Publication statusPublished - Jul 1998


  • C-peptide
  • Pubertal stage
  • Remission
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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