Abstract
To investigate the role of puberty on spontaneous clinical remission and on secretion of residual C-peptide during the first year of type 1 diabetes mellitus, we studied 77 pre-pubertal, 39 pubertal and 41 post-pubertal type 1 diabetic patients. Spontaneous partial clinical remission (HbA(1c) within the normal range and insulin dose less than 0.3 U·kg-1 body weight·day-1 lasting for at least 10 days) decreased with duration of diabetes: months 3 vs 6 vs 12, respectively 13 vs 7 vs 4% (P <0.025). Remission was higher in post-pubertal than pubertal and prepubertal patients: month 6 respectively 20 vs 5 vs 1% (P <0.001). Secretion of C-peptide was significantly lower in pre-pubertal than the other two groups of patients. Basal and stimulated C-peptide secretion were higher in patients in clinical remission than in those who were not: basal value 0.4 (0.26-0.53) vs 0.28 (0.14-0.4) nmol/l (P <0.05); stimulated value 0.63 (0.5-0.95) vs 0.56 (0.31-0.74) nmol/l (P <0.05). Spontaneous remission is less frequent in children and adolescent patients than in adult post-pubertal patients, but different mechanisms may be involved. Low residual insulin secretion seems implicated in children meanwhile low insulin sensitivity could be more important in pubertal patients.
| Original language | English |
|---|---|
| Pages (from-to) | 91-95 |
| Number of pages | 5 |
| Journal | Acta Diabetologica |
| Volume | 35 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jul 1998 |
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Keywords
- C-peptide
- Pubertal stage
- Remission
- Type 1 diabetes mellitus
ASJC Scopus subject areas
- Endocrinology
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Residual beta cell function and spontaneous clinical remission in type 1 diabetes mellitus : The role of puberty. / Bonfanti, R.; Bognetti, E.; Meschi, F.; Brunelli, A.; Riva, M. C.; Pastore, M. R.; Calori, G.; Chiumello, G.
In: Acta Diabetologica, Vol. 35, No. 2, 07.1998, p. 91-95.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Residual beta cell function and spontaneous clinical remission in type 1 diabetes mellitus
T2 - The role of puberty
AU - Bonfanti, R.
AU - Bognetti, E.
AU - Meschi, F.
AU - Brunelli, A.
AU - Riva, M. C.
AU - Pastore, M. R.
AU - Calori, G.
AU - Chiumello, G.
PY - 1998/7
Y1 - 1998/7
N2 - To investigate the role of puberty on spontaneous clinical remission and on secretion of residual C-peptide during the first year of type 1 diabetes mellitus, we studied 77 pre-pubertal, 39 pubertal and 41 post-pubertal type 1 diabetic patients. Spontaneous partial clinical remission (HbA(1c) within the normal range and insulin dose less than 0.3 U·kg-1 body weight·day-1 lasting for at least 10 days) decreased with duration of diabetes: months 3 vs 6 vs 12, respectively 13 vs 7 vs 4% (P <0.025). Remission was higher in post-pubertal than pubertal and prepubertal patients: month 6 respectively 20 vs 5 vs 1% (P <0.001). Secretion of C-peptide was significantly lower in pre-pubertal than the other two groups of patients. Basal and stimulated C-peptide secretion were higher in patients in clinical remission than in those who were not: basal value 0.4 (0.26-0.53) vs 0.28 (0.14-0.4) nmol/l (P <0.05); stimulated value 0.63 (0.5-0.95) vs 0.56 (0.31-0.74) nmol/l (P <0.05). Spontaneous remission is less frequent in children and adolescent patients than in adult post-pubertal patients, but different mechanisms may be involved. Low residual insulin secretion seems implicated in children meanwhile low insulin sensitivity could be more important in pubertal patients.
AB - To investigate the role of puberty on spontaneous clinical remission and on secretion of residual C-peptide during the first year of type 1 diabetes mellitus, we studied 77 pre-pubertal, 39 pubertal and 41 post-pubertal type 1 diabetic patients. Spontaneous partial clinical remission (HbA(1c) within the normal range and insulin dose less than 0.3 U·kg-1 body weight·day-1 lasting for at least 10 days) decreased with duration of diabetes: months 3 vs 6 vs 12, respectively 13 vs 7 vs 4% (P <0.025). Remission was higher in post-pubertal than pubertal and prepubertal patients: month 6 respectively 20 vs 5 vs 1% (P <0.001). Secretion of C-peptide was significantly lower in pre-pubertal than the other two groups of patients. Basal and stimulated C-peptide secretion were higher in patients in clinical remission than in those who were not: basal value 0.4 (0.26-0.53) vs 0.28 (0.14-0.4) nmol/l (P <0.05); stimulated value 0.63 (0.5-0.95) vs 0.56 (0.31-0.74) nmol/l (P <0.05). Spontaneous remission is less frequent in children and adolescent patients than in adult post-pubertal patients, but different mechanisms may be involved. Low residual insulin secretion seems implicated in children meanwhile low insulin sensitivity could be more important in pubertal patients.
KW - C-peptide
KW - Pubertal stage
KW - Remission
KW - Type 1 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=0031669576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031669576&partnerID=8YFLogxK
U2 - 10.1007/s005920050110
DO - 10.1007/s005920050110
M3 - Article
C2 - 9747961
AN - SCOPUS:0031669576
VL - 35
SP - 91
EP - 95
JO - Acta Diabetologica
JF - Acta Diabetologica
SN - 0940-5429
IS - 2
ER -