Residual hazard assessment related to handling of antineoplastic drugs: Safety system evolution and quality assurance of analytical measurement

Roberta Turci, Claudio Minoia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Despite improvement of operating procedures and publication of safety guidelines, contamination is still observed in healthcare settings where antineoplastic drugs (ADs) are handled. Even after cleaning work areas, some residual contamination may still be present. Zero percent contamination is not a realistic goal, but the scientific community should set zero contamination as its main goal. The strategies to reach this objective may be traced based on the followings: (a) a wider number of drugs should be monitored; (b) safety equipment and devices must be available to the workers; (c) the likely source of widespread contamination in workplaces is the safety cabinet; (d) direct determination of the parent drug or its metabolite in urine is the recommended approach because it provides higher sensitivity and specificity; (e) reliable analytical methods are necessary to measure the extent of contamination; and (f) analytical methods intended to be applied for routine testing must be assessed through method validation studies. These studies rely on the determination of overall method performance parameters including uncertainty measurement. Our laboratory has developed and validated a number of analytical methods for the determination of several drugs in environmental and biological samples. Surveys were carried out in several hospitals, and there has been progressive, significant decrease in the number of positive samples, mostly due to the improvement of working procedures and safety measures.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages649-656
Number of pages8
Volume1076
DOIs
Publication statusPublished - Sep 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1076
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Antineoplastic drugs
  • Biological monitoring
  • Environmental monitoring
  • Occupational exposure
  • Quality assurance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Turci, R., & Minoia, C. (2006). Residual hazard assessment related to handling of antineoplastic drugs: Safety system evolution and quality assurance of analytical measurement. In Annals of the New York Academy of Sciences (Vol. 1076, pp. 649-656). (Annals of the New York Academy of Sciences; Vol. 1076). https://doi.org/10.1196/annals.1371.047