Residual ischemia after revascularization in multivessel coronary artery disease: Insights from measurement of absolute myocardial blood flow using magnetic resonance imaging compared with angiographic assessment

Jayanth R. Arnold, Theodoros D. Karamitsos, William J. Van Gaal, Luca Testa, Jane M. Francis, Paul Bhamra-Ariza, Ali Ali, Joseph B. Selvanayagam, Steve Westaby, Rana Sayeed, Michael Jerosch-Herold, Stefan Neubauer, Adrian P. Banning

Research output: Contribution to journalArticle

Abstract

Background-Revascularization strategies for multivessel coronary artery disease include percutaneous coronary intervention and coronary artery bypass grafting. In this study, we compared the completeness of revascularization as assessed by coronary angiography and by quantitative serial perfusion imaging using cardiovascular magnetic resonance. Methods and Results-Patients with multivessel coronary disease were recruited into a randomized trial of treatment with either coronary artery bypass grafting or percutaneous coronary intervention. Angiographic disease burden was determined by the Bypass Angioplasty Revascularization Investigation (BARI) myocardial jeopardy index. Cardiovascular magnetic resonance first-pass perfusion imaging was performed before and 5 to 6 months after revascularization. Using modelindependent deconvolution, hyperemic myocardial blood flow was evaluated, and ischemic burden was quantified. Sixtyseven patients completed follow-up (33 coronary artery bypass grafting and 34 percutaneous coronary intervention). The myocardial jeopardy index was 80.7±15.2% at baseline and 6.9±11.3% after revascularization (P

Original languageEnglish
Pages (from-to)237-245
Number of pages9
JournalCirculation: Cardiovascular Interventions
Volume6
Issue number3
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Bypass surgery
  • Revascularization
  • Stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Arnold, J. R., Karamitsos, T. D., Van Gaal, W. J., Testa, L., Francis, J. M., Bhamra-Ariza, P., Ali, A., Selvanayagam, J. B., Westaby, S., Sayeed, R., Jerosch-Herold, M., Neubauer, S., & Banning, A. P. (2013). Residual ischemia after revascularization in multivessel coronary artery disease: Insights from measurement of absolute myocardial blood flow using magnetic resonance imaging compared with angiographic assessment. Circulation: Cardiovascular Interventions, 6(3), 237-245. https://doi.org/10.1161/CIRCINTERVENTIONS.112.000064