Residual platelet reactivity is an independent predictor of myocardial injury in acute myocardial infarction patients on antiaggregant therapy

Rossella Marcucci, Rita Paniccia, Emilia Antonucci, Serena Poli, Anna Maria Gori, Serafina Valente, Cristina Giglioli, Chiara Lazzeri, Domenico Prisco, Rosanna Abbate, Gian Franco Gensini

Research output: Contribution to journalArticle

Abstract

In this study we sought to evaluate if platelet function measured after percutaneous coronary intervention (PCI) affects the severity of myocardial infarction (MI), measured by markers of cardiac necrosis. We measured platelet function by both a point-of-care assay (PFA-100) and platelet-rich plasma aggregation by two agonists (arachidonic acid -AA- and 2 and 10 μM ADP) in 367 patients with MI after PCI (200 patients on dual antiplatelet agents - group A- and 167 on dual antiplatelet agents plus GpIIb/IIIa inhibitors - group B). One hundred twenty-one (32.9%) patients were found to have a residual platelet reactivity (RPR) by PFA (CT/EPI

Original languageEnglish
Pages (from-to)844-851
Number of pages8
JournalThrombosis and Haemostasis
Volume98
Issue number4
DOIs
Publication statusPublished - Oct 2007

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Blood Platelets
Platelet Aggregation Inhibitors
Myocardial Infarction
Percutaneous Coronary Intervention
Wounds and Injuries
Point-of-Care Systems
Platelet-Rich Plasma
Arachidonic Acid
Adenosine Diphosphate
Necrosis
Therapeutics

Keywords

  • Aspirin resistance
  • Clopidogrel resistance
  • Myocardial infarction
  • Myonecrosis
  • Post-treatment platelet reactivity

ASJC Scopus subject areas

  • Hematology

Cite this

Residual platelet reactivity is an independent predictor of myocardial injury in acute myocardial infarction patients on antiaggregant therapy. / Marcucci, Rossella; Paniccia, Rita; Antonucci, Emilia; Poli, Serena; Gori, Anna Maria; Valente, Serafina; Giglioli, Cristina; Lazzeri, Chiara; Prisco, Domenico; Abbate, Rosanna; Gensini, Gian Franco.

In: Thrombosis and Haemostasis, Vol. 98, No. 4, 10.2007, p. 844-851.

Research output: Contribution to journalArticle

Marcucci, R, Paniccia, R, Antonucci, E, Poli, S, Gori, AM, Valente, S, Giglioli, C, Lazzeri, C, Prisco, D, Abbate, R & Gensini, GF 2007, 'Residual platelet reactivity is an independent predictor of myocardial injury in acute myocardial infarction patients on antiaggregant therapy', Thrombosis and Haemostasis, vol. 98, no. 4, pp. 844-851. https://doi.org/10.1160/TH06-11-0618
Marcucci, Rossella ; Paniccia, Rita ; Antonucci, Emilia ; Poli, Serena ; Gori, Anna Maria ; Valente, Serafina ; Giglioli, Cristina ; Lazzeri, Chiara ; Prisco, Domenico ; Abbate, Rosanna ; Gensini, Gian Franco. / Residual platelet reactivity is an independent predictor of myocardial injury in acute myocardial infarction patients on antiaggregant therapy. In: Thrombosis and Haemostasis. 2007 ; Vol. 98, No. 4. pp. 844-851.
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AU - Valente, Serafina

AU - Giglioli, Cristina

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