Abstract
Residual renal function (RRF) has been associated with a better nutritional status in adult patients on chronic dialysis, but there is as yet no data available for young patients on chronic hemodialysis (HD). We have retrospectively analyzed 3-day dietary reports and simultaneous urea kinetic monitoring data (n = 179) of 30 children, adolescents and young adults on chronic HD. The protein catabolic rate (PCR) was calculated and normalized by body weight (nPCR). The HD dialysis dose (Kt/VHD), RRF (calculated by urea clearance, Ku, and expressed as residual Kt/V) and total Kt/V (Kt/Vtot) were evaluated. In all patients, nPCR was correlated with dietary protein intake (nDPI) (p <0.0001) and Kt/Vtot (p <0.0001) but not with Kt/VHD (p = 0.11). In patients with RRF, Ku was associated with nPCR (p <0.0001), while Kt/VHD was not (p = 0.10), and nPCR was higher than in patients without RRF (1.46 ± 0.41 vs. 1.03 ± 0.33 g/kg/day; p <0.0001). Patients on recombinant growth hormone (rhGH) treatment showed higher nPCR values than those without rhGH (1.34 ± 0.41 vs. 1.01 ± 0.39 g/kg/day; p <0.0001). In a multiple regression model including age, rhGH treatment, RRF, Kt/Vtot and Kt/VHD, and nPCR showed the best correlation with RRF (β = 0.128; p <0.0001). In conclusion, in children, adolescents and young adults on chronic HD treatment, RRF positively affects nutrition independently of HD efficiency and rhGH treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 1391-1397 |
| Number of pages | 7 |
| Journal | Pediatric Nephrology |
| Volume | 24 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Chronic hemodialysis
- Nutrition
- Protein catabolic rate
- Recombinant human growth hormone
- Residual renal function
ASJC Scopus subject areas
- Nephrology
- Pediatrics, Perinatology, and Child Health
Cite this
Residual renal function and nutrition in young patients on chronic hemodialysis. / Guzzo, Isabella; Mancini, Elvira; Kengne Wafo, Séverin; Ravà, Lucilla; Picca, Stefano.
In: Pediatric Nephrology, Vol. 24, No. 7, 2009, p. 1391-1397.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Residual renal function and nutrition in young patients on chronic hemodialysis
AU - Guzzo, Isabella
AU - Mancini, Elvira
AU - Kengne Wafo, Séverin
AU - Ravà, Lucilla
AU - Picca, Stefano
PY - 2009
Y1 - 2009
N2 - Residual renal function (RRF) has been associated with a better nutritional status in adult patients on chronic dialysis, but there is as yet no data available for young patients on chronic hemodialysis (HD). We have retrospectively analyzed 3-day dietary reports and simultaneous urea kinetic monitoring data (n = 179) of 30 children, adolescents and young adults on chronic HD. The protein catabolic rate (PCR) was calculated and normalized by body weight (nPCR). The HD dialysis dose (Kt/VHD), RRF (calculated by urea clearance, Ku, and expressed as residual Kt/V) and total Kt/V (Kt/Vtot) were evaluated. In all patients, nPCR was correlated with dietary protein intake (nDPI) (p <0.0001) and Kt/Vtot (p <0.0001) but not with Kt/VHD (p = 0.11). In patients with RRF, Ku was associated with nPCR (p <0.0001), while Kt/VHD was not (p = 0.10), and nPCR was higher than in patients without RRF (1.46 ± 0.41 vs. 1.03 ± 0.33 g/kg/day; p <0.0001). Patients on recombinant growth hormone (rhGH) treatment showed higher nPCR values than those without rhGH (1.34 ± 0.41 vs. 1.01 ± 0.39 g/kg/day; p <0.0001). In a multiple regression model including age, rhGH treatment, RRF, Kt/Vtot and Kt/VHD, and nPCR showed the best correlation with RRF (β = 0.128; p <0.0001). In conclusion, in children, adolescents and young adults on chronic HD treatment, RRF positively affects nutrition independently of HD efficiency and rhGH treatment.
AB - Residual renal function (RRF) has been associated with a better nutritional status in adult patients on chronic dialysis, but there is as yet no data available for young patients on chronic hemodialysis (HD). We have retrospectively analyzed 3-day dietary reports and simultaneous urea kinetic monitoring data (n = 179) of 30 children, adolescents and young adults on chronic HD. The protein catabolic rate (PCR) was calculated and normalized by body weight (nPCR). The HD dialysis dose (Kt/VHD), RRF (calculated by urea clearance, Ku, and expressed as residual Kt/V) and total Kt/V (Kt/Vtot) were evaluated. In all patients, nPCR was correlated with dietary protein intake (nDPI) (p <0.0001) and Kt/Vtot (p <0.0001) but not with Kt/VHD (p = 0.11). In patients with RRF, Ku was associated with nPCR (p <0.0001), while Kt/VHD was not (p = 0.10), and nPCR was higher than in patients without RRF (1.46 ± 0.41 vs. 1.03 ± 0.33 g/kg/day; p <0.0001). Patients on recombinant growth hormone (rhGH) treatment showed higher nPCR values than those without rhGH (1.34 ± 0.41 vs. 1.01 ± 0.39 g/kg/day; p <0.0001). In a multiple regression model including age, rhGH treatment, RRF, Kt/Vtot and Kt/VHD, and nPCR showed the best correlation with RRF (β = 0.128; p <0.0001). In conclusion, in children, adolescents and young adults on chronic HD treatment, RRF positively affects nutrition independently of HD efficiency and rhGH treatment.
KW - Chronic hemodialysis
KW - Nutrition
KW - Protein catabolic rate
KW - Recombinant human growth hormone
KW - Residual renal function
UR - http://www.scopus.com/inward/record.url?scp=67349271546&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349271546&partnerID=8YFLogxK
U2 - 10.1007/s00467-009-1144-7
DO - 10.1007/s00467-009-1144-7
M3 - Article
C2 - 19271246
AN - SCOPUS:67349271546
VL - 24
SP - 1391
EP - 1397
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 7
ER -