Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL

Nicola Gianotti; Laura Galli; Sara Racca; Stefania Salpietro; Francesca Cossarini; Vincenzo Spagnuolo; Beatrice Barda; Filippo Canducci; Massimo Clementi; Adriano Lazzarin; Antonella Castagna

doi:10.1093/jac/dkr422

Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL

Nicola Gianotti, Laura Galli, Sara Racca, Stefania Salpietro, Francesca Cossarini, Vincenzo Spagnuolo, Beatrice Barda, Filippo Canducci, Massimo Clementi, Adriano Lazzarin, Antonella Castagna

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

Objectives: It is currently debated whether patients with residual viraemia are at higher risk of virological failure than those attaining 50 copies/mL after baseline, and the time to virological rebound was calculated using the Kaplan-Meier method. Results: There were 739 eligible patients; 446 (60.4%) had HIV RNA 3 per year versus +21.2 (22.5, 53.2)cells/mm³ per year; P1/40.036. Conclusions: Residual viraemia assessed by kPCR was not associated with virological rebound during 1 year of follow-up. However, the patients attaining

Original language	English
Pages (from-to)	213-217
Number of pages	5
Journal	Journal of Antimicrobial Chemotherapy
Volume	67
Issue number	1
DOIs	https://doi.org/10.1093/jac/dkr422
Publication status	Published - 2012

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Keywords

Antiretroviral therapy
HIV-1 viral load
Immune recovery
kPCR
Virological failure

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases
Medicine(all)

Cite this

Gianotti, N., Galli, L., Racca, S., Salpietro, S., Cossarini, F., Spagnuolo, V., Barda, B., Canducci, F., Clementi, M., Lazzarin, A., & Castagna, A. (2012). Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL. Journal of Antimicrobial Chemotherapy, 67(1), 213-217. https://doi.org/10.1093/jac/dkr422

Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL. / Gianotti, Nicola ; Galli, Laura; Racca, Sara; Salpietro, Stefania; Cossarini, Francesca; Spagnuolo, Vincenzo; Barda, Beatrice; Canducci, Filippo; Clementi, Massimo; Lazzarin, Adriano; Castagna, Antonella.

In: Journal of Antimicrobial Chemotherapy, Vol. 67, No. 1, 2012, p. 213-217.

Research output: Contribution to journal › Article

Gianotti, N , Galli, L, Racca, S, Salpietro, S, Cossarini, F, Spagnuolo, V, Barda, B, Canducci, F, Clementi, M, Lazzarin, A & Castagna, A 2012, 'Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL', Journal of Antimicrobial Chemotherapy, vol. 67, no. 1, pp. 213-217. https://doi.org/10.1093/jac/dkr422

Gianotti, Nicola ; Galli, Laura ; Racca, Sara ; Salpietro, Stefania ; Cossarini, Francesca ; Spagnuolo, Vincenzo ; Barda, Beatrice ; Canducci, Filippo ; Clementi, Massimo ; Lazzarin, Adriano ; Castagna, Antonella. / Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL. In: Journal of Antimicrobial Chemotherapy. 2012 ; Vol. 67, No. 1. pp. 213-217.

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AU - Cossarini, Francesca

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AU - Barda, Beatrice

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10.1093/jac/dkr422