Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL

Nicola Gianotti; Laura Galli; Sara Racca; Stefania Salpietro; Francesca Cossarini; Vincenzo Spagnuolo; Beatrice Barda; Filippo Canducci; Massimo Clementi; Adriano Lazzarin; Antonella Castagna

doi:10.1093/jac/dkr422

Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL

Nicola Gianotti, Laura Galli, Sara Racca, Stefania Salpietro, Francesca Cossarini, Vincenzo Spagnuolo, Beatrice Barda, Filippo Canducci, Massimo Clementi, Adriano Lazzarin, Antonella Castagna

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: It is currently debated whether patients with residual viraemia are at higher risk of virological failure than those attaining 50 copies/mL after baseline, and the time to virological rebound was calculated using the Kaplan-Meier method. Results: There were 739 eligible patients; 446 (60.4%) had HIV RNA 3 per year versus +21.2 (22.5, 53.2)cells/mm³ per year; P1/40.036. Conclusions: Residual viraemia assessed by kPCR was not associated with virological rebound during 1 year of follow-up. However, the patients attaining

Original language	English
Pages (from-to)	213-217
Number of pages	5
Journal	Journal of Antimicrobial Chemotherapy
Volume	67
Issue number	1
DOIs	https://doi.org/10.1093/jac/dkr422
Publication status	Published - 2012

Keywords

Antiretroviral therapy
HIV-1 viral load
Immune recovery
kPCR
Virological failure

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases
Medicine(all)

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10.1093/jac/dkr422

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Gianotti, N., Galli, L., Racca, S., Salpietro, S., Cossarini, F., Spagnuolo, V., Barda, B., Canducci, F., Clementi, M., Lazzarin, A., & Castagna, A. (2012). Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL. Journal of Antimicrobial Chemotherapy, 67(1), 213-217. https://doi.org/10.1093/jac/dkr422

Gianotti, N , Galli, L, Racca, S, Salpietro, S, Cossarini, F, Spagnuolo, V, Barda, B, Canducci, F, Clementi, M, Lazzarin, A & Castagna, A 2012, 'Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL', Journal of Antimicrobial Chemotherapy, vol. 67, no. 1, pp. 213-217. https://doi.org/10.1093/jac/dkr422

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abstract = "Objectives: It is currently debated whether patients with residual viraemia are at higher risk of virological failure than those attaining 50 copies/mL after baseline, and the time to virological rebound was calculated using the Kaplan-Meier method. Results: There were 739 eligible patients; 446 (60.4%) had HIV RNA 3 per year versus +21.2 (22.5, 53.2)cells/mm3 per year; P1/40.036. Conclusions: Residual viraemia assessed by kPCR was not associated with virological rebound during 1 year of follow-up. However, the patients attaining ",

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author = "Nicola Gianotti and Laura Galli and Sara Racca and Stefania Salpietro and Francesca Cossarini and Vincenzo Spagnuolo and Beatrice Barda and Filippo Canducci and Massimo Clementi and Adriano Lazzarin and Antonella Castagna",

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T1 - Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL

AU - Gianotti, Nicola

AU - Galli, Laura

AU - Racca, Sara

AU - Salpietro, Stefania

AU - Cossarini, Francesca

AU - Spagnuolo, Vincenzo

AU - Barda, Beatrice

AU - Canducci, Filippo

AU - Clementi, Massimo

AU - Lazzarin, Adriano

AU - Castagna, Antonella

PY - 2012

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AB - Objectives: It is currently debated whether patients with residual viraemia are at higher risk of virological failure than those attaining 50 copies/mL after baseline, and the time to virological rebound was calculated using the Kaplan-Meier method. Results: There were 739 eligible patients; 446 (60.4%) had HIV RNA 3 per year versus +21.2 (22.5, 53.2)cells/mm3 per year; P1/40.036. Conclusions: Residual viraemia assessed by kPCR was not associated with virological rebound during 1 year of follow-up. However, the patients attaining

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KW - HIV-1 viral load

KW - Immune recovery

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KW - Virological failure

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Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL

Abstract

Keywords

ASJC Scopus subject areas

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