Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL

Nicola Gianotti, Laura Galli, Sara Racca, Stefania Salpietro, Francesca Cossarini, Vincenzo Spagnuolo, Beatrice Barda, Filippo Canducci, Massimo Clementi, Adriano Lazzarin, Antonella Castagna

Research output: Contribution to journalArticle


Objectives: It is currently debated whether patients with residual viraemia are at higher risk of virological failure than those attaining 50 copies/mL after baseline, and the time to virological rebound was calculated using the Kaplan-Meier method. Results: There were 739 eligible patients; 446 (60.4%) had HIV RNA 3 per year versus +21.2 (22.5, 53.2)cells/mm3 per year; P1/40.036. Conclusions: Residual viraemia assessed by kPCR was not associated with virological rebound during 1 year of follow-up. However, the patients attaining

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Issue number1
Publication statusPublished - 2012



  • Antiretroviral therapy
  • HIV-1 viral load
  • Immune recovery
  • kPCR
  • Virological failure

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases
  • Medicine(all)

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