Resistance of uropathogens to antibacterial agents: Emerging threats, trends and treatments

Gianpaolo Perletti, Vittorio Magri, Tommaso Cai, Konstantinos Stamatiou, Alberto Trinchieri, Emanuele Montanari

Research output: Contribution to journalReview articlepeer-review

Abstract

Urinary tract infections are among the most common infectious diseases in humans. Today, resistance to nearly all antimicrobial classes is dramatically growing, and extremely drug-resistant or even pan-drug resistant pathogens are increasingly isolated around the world. It is foreseen that in the next decades the world will be facing a major medical emergency generated by the rapid spread of pathogens carrying resistance determinants of unprecedented power. Carbapenemase-producing Enterobacteriaceae, multidrug-resistant Enterococci and fluoroquinolone resistance determinants in both Gram-negative and Gram-positive uropathogens are among the greatest emergencies. In this article, the major emerging threats of particular interest to urologists are reviewed, worldwide resistance trends are illustrated, and novel and older-but still active-recommended drugs are summarized.

Original languageEnglish
Pages (from-to)85-96
Number of pages12
JournalArchivio Italiano di Urologia e Andrologia
Volume9
Issue number2
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Antibacterial agents
  • Antibiotics
  • Carbapenem resistance
  • Carbapenemase
  • Resistance
  • Urinary tract infections

ASJC Scopus subject areas

  • Urology

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