Resistance to Antibiotics of Uropathogen Bacteria Isolated From Urine and Blood in Pediatric Cancer Patients: A Single Center, 12-year Study

Francesca Landi, Roberto Bandettini, Gioacchino Andrea Rotulo, Alessio Mesini, Carolina Saffioti, Loredana Amoroso, Filomena Pierri, Daniela Guardo, Elio Castagnola

Research output: Contribution to journalArticlepeer-review

Abstract

Resistant pathogens have become a major healthcare problem in children with cancer, causing different kinds of infections such as the bloodstream ones, most common, and most frequently described and the urinary tract ones, of which less data are available. We analyzed and compared the proportions, and the trends of resistance in pathogens isolated from blood and urines in children with cancer followed in IRCCS Istituto Giannina Gaslini, Genova, Italy, from January 2007 to December 2018. Overall, 345 strains detected in urines and 282 in bloodstream infections were analyzed. Enterobacteriales were the most frequently isolated pathogens. During the study period in urines, there was a significant increase of resistance to ceftazidime, ciprofloxacin, piperacillin/tazobactam, and trimethoprim-sulfamethoxazole, but pathogens from blood were significantly more frequently resistant to amikacin, piperacillin/tazobactam, and combination therapy piperacillin/tazobactam+amikacin, even if with a decreasing trend during the study period. These data confirm the importance of surveillance of isolated microorganism and antibiotic resistance in cancer children.

Original languageEnglish
Pages (from-to)1106-1110
Number of pages5
JournalThe Pediatric infectious disease journal
Volume39
Issue number12
DOIs
Publication statusPublished - Dec 2020

Fingerprint

Dive into the research topics of 'Resistance to Antibiotics of Uropathogen Bacteria Isolated From Urine and Blood in Pediatric Cancer Patients: A Single Center, 12-year Study'. Together they form a unique fingerprint.

Cite this