Resistance to recombinant alpha interferon therapy in idiopathic mixed cryoglobulinemia: Reinduction of remission by natural alpha interferon both in antibody-positive and -negative patients

M. Casato, G. Antonelli, F. Maggi, L. P. Pucillo, L. Di Lullo, M. Leoni, M. Currenti, F. Dianzani, L. Bonomo

Research output: Contribution to journalArticlepeer-review

Abstract

A subset of patients treated with recombinant interferon α-2a (rIFN-α2a) for idiopathic mixed cryoglobulinemia (IMC) developed clinical resistance to therapy after a sustained response. Neutralizing antibodies to rIFN-α2a were found in the sera of three out of four such patients, and in none of the patients who remained responsive to treatment. rIFN-α2a neutralizing antibodies appeared in serum samples of the former three patients 1, 5 and 6 months before evidence for clinical resistance, respectively. Antibody titres to rIFN-α2a were consistently higher than those to natural interferon (nIFN). In the fourth patient with clinical resistance, neutralizing antibodies could not be detected by a very sensitive bioassay in any of several serum samples taken before and after relapse. All the four patients could be reinduced into remission by the administration of nIFN-α. These data indicate that mechanisms other than the production of neutralizing antibodies can mediate acquired resistance to IFN therapy. Furthermore, both antibody-related and -unrelated resistance can be overcome by switching to different species of IFN-α.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalJournal of Biological Regulators and Homeostatic Agents
Volume8
Issue number2
Publication statusPublished - 1994

Keywords

  • cryoglobulinemia
  • interferon
  • neutralizing antibodies

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)

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