Resistance to striatal dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice expressing human mutant Cu,Zn superoxide dismutase

Francesco Fornai, Maria Teresa Carrì, Alberto Ferri, Egle Paolucci, Simona Prisco, Giorgio Bernardi, Giuseppe Rotilio, Nicola Biagio Mercuri

Research output: Contribution to journalArticlepeer-review

Abstract

Recent data indicate that overexpression of the enzyme Cu,Zn superoxide dismutase (SOD1) in mice confers neuroprotection against various dopamine neurotoxins like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), methamphetamine, 6-hydroxydopamine and methylenedioxymethamphetamine. In the present study we investigated whether a mutant form of SOD1 (G93A), occurring in humans affected by amyotrophic lateral sclerosis, leads to a differential vulnerability of nigrostriatal dopaminergic neurons to the chronic dopamine depletion induced by the selective neurotoxin MPTP. Our results indicate that overexpression of both wild-type and human mutant SOD1 induces comparable neuroprotective effects against striatal dopaminergic depletion.

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalNeuroscience Letters
Volume325
Issue number2
DOIs
Publication statusPublished - Jun 7 2002

Keywords

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Amyotrophic lateral sclerosis
  • Oxidative stress
  • Parkinson's disease
  • Reactive oxygen species
  • Superoxide dismutase

ASJC Scopus subject areas

  • Neuroscience(all)

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