Resistance to the cytocidal effects of adriamycin is an early phenotypic change induced during hepatocarcinogenesis

B. I. Carr, B. A. Laishes

Research output: Contribution to journalArticle

Abstract

Resistance to the cytocidal action of Adriamycin (ADR) was induced in rat hepatocytes by incorporation of the carcinogen 2-acetylaminofluorene (AAF) into the rat diet. Using a quantitative assay in primary monolayer culture, it was demonstrated that resistance to ADR is an early phenotypic change that is induced during chemical carcinogenesis in the rat, and appears to be stable.

Original languageEnglish
Pages (from-to)567-571
Number of pages5
JournalBritish Journal of Cancer
Volume44
Issue number4
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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