Resistance to the cytocidal action of Adriamycin (ADR) was induced in rat hepatocytes by incorporation of the carcinogen 2-acetylaminofluorene (AAF) into the rat diet. Using a quantitative assay in primary monolayer culture, it was demonstrated that resistance to ADR is an early phenotypic change that is induced during chemical carcinogenesis in the rat, and appears to be stable.
|Number of pages||5|
|Journal||British Journal of Cancer|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Cancer Research