Resistin is associated with overall survival in non-small cell lung cancer patients during nivolumab treatment

A. Bonaventura, F. Grossi, F. Carbone, A. Vecchié, S. Minetti, N. Bardi, E. Elia, A. M. Ansaldo, D. Ferrara, E. Rijavec, M. G. Dal Bello, G. Rossi, F. Biello, M. Tagliamento, A. Alama, S. Coco, P. Spallarossa, F. Dallegri, C. Genova, F. Montecucco

Research output: Contribution to journalArticle

Abstract

Purpose: Since the role of resistin was evaluated only in patients with non-small cell lung cancer (NSCLC) not treated with immunotherapy, we aimed to evaluate levels of resistin during immunotherapy (nivolumab) and its prognostic role with regard to OS. Methods/patients: From a cohort of 78 patients with advanced NSCLC enrolled in a prospective study at Ospedale Policlinico San Martino in Genoa (Italy), 43 patients have been considered for this sub-analysis because of the availability of samples. Before and during nivolumab administration, clinical information and blood samples were collected and resistin, matrix metalloproteinase (MMP)-8, MMP-9, and myeloperoxidase were evaluated by enzyme-linked immunosorbent assay (ELISA). Results: Median age was 71 with a prevalence of males and former smokers. Median resistin levels presented a peak at cycle 2 and then dropped down until the last cycle. Resistin correlated with all neutrophil degranulation products at cycle 1 (except for MMP-9) and at cycle 2 as well as with white blood cells and neutrophils. By a ROC curve analysis, a resistin value at cycle 2 of 19 ng/mL was tested as the best cut-off point for OS. Kaplan–Meier analysis demonstrated that patients above the resistin cut-off experienced a reduced OS (median OS 242.5 vs. 470 days, p = 0.0073), as confirmed by Cox proportional hazards regression analysis. Conclusions: Resistin levels > 19 ng/mL at the time of the second cycle of nivolumab treatment independently predict a reduced OS in patients with advanced NSCLC.

Original languageEnglish
JournalClinical and Translational Oncology
DOIs
Publication statusAccepted/In press - Jan 1 2020

Keywords

  • Immunotherapy
  • Lung cancer
  • Neutrophils
  • Nivolumab
  • NSCLC
  • Resistin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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