Resistin level in coronary artery disease and heart failure: The central role of kidney function

Samuele Baldasseroni, Edoardo Mannucci, Claudia Di Serio, Francesco Orso, Nadia Bartoli, Enrico Mossello, Alice Foschini, Matteo Monami, Paolo Valoti, Stefano Fumagalli, Claudia Colombi, Silvia Pellerito, Gianfranco Gensini, Niccolò Marchionni, Francesca Tarantini

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: The aim of this study was to evaluate resistin levels in patients with coronary artery disease (CAD) with or without chronic heart failure, in order to define its independent predictor. METHODS: One hundred and seven outpatients with CAD were enrolled in the study and divided into three groups: CAD without left-ventricular systolic dysfunction (group 1); CAD with left-ventricular dysfunction without heart failure symptoms (group 2); CAD with overt heart failure (group 3). Plasma resistin was determined by ELISA. RESULTS: Resistin progressively increased from group 1 (10. 7 ±â€Š5.0 ng/ ml) to groups 2 (11.8 ±â€Š5. 8 ng/ml) and 3 (17. 0 ±â€Š6.8 ng/ ml), with the difference reaching statistical significance in group 3 versus groups 1 and 2 (P = 0.001). A multivariable model of analysis demonstrated that the best predictor of plasma resistin level was the estimated glomerular filtration rate (P†Š

Original languageEnglish
Pages (from-to)150-157
Number of pages8
JournalJournal of Cardiovascular Medicine
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • adipokine
  • chronic heart failure
  • coronary artery disease
  • kidney function
  • resistin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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