TY - JOUR
T1 - Resistin level in coronary artery disease and heart failure
T2 - The central role of kidney function
AU - Baldasseroni, Samuele
AU - Mannucci, Edoardo
AU - Di Serio, Claudia
AU - Orso, Francesco
AU - Bartoli, Nadia
AU - Mossello, Enrico
AU - Foschini, Alice
AU - Monami, Matteo
AU - Valoti, Paolo
AU - Fumagalli, Stefano
AU - Colombi, Claudia
AU - Pellerito, Silvia
AU - Gensini, Gianfranco
AU - Marchionni, Niccolò
AU - Tarantini, Francesca
PY - 2013/2
Y1 - 2013/2
N2 - OBJECTIVES: The aim of this study was to evaluate resistin levels in patients with coronary artery disease (CAD) with or without chronic heart failure, in order to define its independent predictor. METHODS: One hundred and seven outpatients with CAD were enrolled in the study and divided into three groups: CAD without left-ventricular systolic dysfunction (group 1); CAD with left-ventricular dysfunction without heart failure symptoms (group 2); CAD with overt heart failure (group 3). Plasma resistin was determined by ELISA. RESULTS: Resistin progressively increased from group 1 (10. 7 ±â€Š5.0 ng/ ml) to groups 2 (11.8 ±â€Š5. 8 ng/ml) and 3 (17. 0 ±â€Š6.8 ng/ ml), with the difference reaching statistical significance in group 3 versus groups 1 and 2 (P = 0.001). A multivariable model of analysis demonstrated that the best predictor of plasma resistin level was the estimated glomerular filtration rate (P†Š
AB - OBJECTIVES: The aim of this study was to evaluate resistin levels in patients with coronary artery disease (CAD) with or without chronic heart failure, in order to define its independent predictor. METHODS: One hundred and seven outpatients with CAD were enrolled in the study and divided into three groups: CAD without left-ventricular systolic dysfunction (group 1); CAD with left-ventricular dysfunction without heart failure symptoms (group 2); CAD with overt heart failure (group 3). Plasma resistin was determined by ELISA. RESULTS: Resistin progressively increased from group 1 (10. 7 ±â€Š5.0 ng/ ml) to groups 2 (11.8 ±â€Š5. 8 ng/ml) and 3 (17. 0 ±â€Š6.8 ng/ ml), with the difference reaching statistical significance in group 3 versus groups 1 and 2 (P = 0.001). A multivariable model of analysis demonstrated that the best predictor of plasma resistin level was the estimated glomerular filtration rate (P†Š
KW - adipokine
KW - chronic heart failure
KW - coronary artery disease
KW - kidney function
KW - resistin
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U2 - 10.2459/JCM.0b013e32834eec93
DO - 10.2459/JCM.0b013e32834eec93
M3 - Article
C2 - 22240747
AN - SCOPUS:84873090731
VL - 14
SP - 150
EP - 157
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
SN - 1558-2027
IS - 2
ER -