Resolution-dependent estimates of lesion volumes in magnetic resonance imaging studies of the brain in multiple sclerosis

M. Filippi, M. A. Horsfield, A. Campi, S. Mammi, C. Pereira, G. Comi

Research output: Contribution to journalArticle

Abstract

In this study, we investigated the relationship between multiple sclerosis lesion volumes measured from magnetic resonance imaging scans and image- slice thickness. The lesion volume was computed using a semiautomated thresholding technique from axial scans of the brain of varying slice thickness. Ten patients were studied, and in all cases the computed lesion volume increased with decreasing slice thickness (p = 0.01). Linear extrapolation from our data allowed the lesion volume at very small slice thickness to be estimated; this was found to be on average 20% greater than that obtained using a slice thickness of 5 min. Furthermore, there were considerable differences in the percentage of change in lesion volume from patient to patient, and it would appear that there is a larger variation with slice thickness for patients with smaller lesions and higher lesion loads.

Original languageEnglish
Pages (from-to)749-754
Number of pages6
JournalAnnals of Neurology
Volume38
Issue number5
DOIs
Publication statusPublished - Nov 1995

ASJC Scopus subject areas

  • Neuroscience(all)

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