Resolution of cystoid macular edema following arginine-restricted diet and vitamin B6 supplementation in a case of gyrate atrophy

Giuseppe Casalino, L Pierro, MP Manitto, M Michaelides, F Bandello

Research output: Contribution to journalArticle

Abstract

We report the outcome of 3 years of arginine-restricted diet and vitamin B6 supplementation in a boy who presented with gyrate atrophy of the choroid and retina and bilateral cystoid macular edema. The diagnosis of gyrate atrophy was made on the basis of clinical findings and increased plasma ornithine levels. Molecular genetic testing revealed a disease-causing homozygous mutation in the ornithine aminotransferase (OAT) gene. After 3 months of dietary modification and pyridoxine supplementation, visual acuity improved, and optical coherence tomography showed resolution of cystoid macular edema in both eyes. This anatomical and functional improvement was maintained during 3 years of follow-up. © 2018 American Association for Pediatric Ophthalmology and Strabismus
Original languageEnglish
Pages (from-to)321-323
Number of pages3
JournalJournal of AAPOS
Volume22
Issue number4
DOIs
Publication statusPublished - 2018

Fingerprint

Gyrate Atrophy
Vitamin B 6
Macular Edema
Arginine
Ornithine-Oxo-Acid Transaminase
Diet
Diet Therapy
Pyridoxine
Ornithine
Optical Coherence Tomography
Genetic Testing
Visual Acuity
Molecular Biology
Mutation
Genes

Cite this

Resolution of cystoid macular edema following arginine-restricted diet and vitamin B6 supplementation in a case of gyrate atrophy. / Casalino, Giuseppe; Pierro, L; Manitto, MP; Michaelides, M; Bandello, F.

In: Journal of AAPOS, Vol. 22, No. 4, 2018, p. 321-323.

Research output: Contribution to journalArticle

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