Resolution of immune haemolytic anaemia with allogeneic bone marrow transplantation after an unsuccessful autograft

Piero De Stefano, Marco Zecca, Giovanna Giorgiani, Cesare Perotti, Eugenia Giraldi, Franco Locatelli

Research output: Contribution to journalArticlepeer-review

Abstract

Autologous transplantation of lymphocyte-depleted peripheral blood stem cells (PBSC) has been proposed for treatment of patients with severe autoimmune disease. However, several patients have been reported to achieve only transient remissions. We report on a child with thalassaemia intermedia and immune-mediated haemolytic anaemia, given an autologous lymphocyte- depleted PBSC transplant, who relapsed 7 weeks after transplant. A complete remission, lasting 18 months to date, was obtained with allogeneic bone marrow transplantation (BMT) from an HLA-matched unrelated donor. This experience indicates that, in selected cases, allogeneic BMT may be the treatment of choice for life-threatening autoimmune disease. A graft-versus- autoimmunity effect may favour the eradication of the recipient autoaggressive lymphocytes.

Original languageEnglish
Pages (from-to)1063-1064
Number of pages2
JournalBritish Journal of Haematology
Volume106
Issue number4
DOIs
Publication statusPublished - 1999

Keywords

  • Autoimmune disease
  • Bone marrow transplantation
  • Immune haemolytic anaemia
  • Immunosuppressive treatment
  • Thalassaemia

ASJC Scopus subject areas

  • Hematology

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