Respirator management of sepsis-related respiratory failure

Davide Chiumello, Massimo Cressoni

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The first description of acute respiratory distress syndrome (ARDS) in adults appeared in 1967 and was characterized by dyspnea, hypoxemia, diffuse alveolar infiltrates, and reduced respiratory system compliance. ARDS and acute lung injury (ALI) syndrome have no specific treatment, only supportive care: treating the underlying cause, when possible, and using mechanical ventilation. Historically, mechanical ventilation applied normal/large tidal volumes and low levels of positive end-expiratory pressure (PEEP). Experimental data showed that a high-volume, high-pressure ventilation strategy may lead to lung lesions indistinguishable from ARDS. Subsequent randomized clinical trials showed improved survival using low tidal volumes (6 vs 12 mL/kg ideal body weight) and limiting plateau pressure to 30 cm H 2O, although the optimal level of PEEP remains controversial. Prone positioning should be reserved for severely ill patients. Inhaled nitric oxide, which is a pulmonary vasodilator with anti-inflammatory properties, is associated with limited improvement in oxygenation without improvement in survival.

Original languageEnglish
Pages (from-to)365-371
Number of pages7
JournalCurrent Infectious Disease Reports
Volume11
Issue number5
DOIs
Publication statusPublished - 2009

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Adult Respiratory Distress Syndrome
Mechanical Ventilators
Respiratory Insufficiency
Sepsis
Positive-Pressure Respiration
Tidal Volume
Artificial Respiration
Pressure
Ideal Body Weight
Lung
Survival
Acute Lung Injury
Vasodilator Agents
Respiratory System
Dyspnea
Compliance
Ventilation
Nitric Oxide
Anti-Inflammatory Agents
Randomized Controlled Trials

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Respirator management of sepsis-related respiratory failure. / Chiumello, Davide; Cressoni, Massimo.

In: Current Infectious Disease Reports, Vol. 11, No. 5, 2009, p. 365-371.

Research output: Contribution to journalArticle

Chiumello, Davide ; Cressoni, Massimo. / Respirator management of sepsis-related respiratory failure. In: Current Infectious Disease Reports. 2009 ; Vol. 11, No. 5. pp. 365-371.
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