Respiratory effects of labetalol in anginous or hypertensive patients

C. Mazzola, E. Guffanti, A. Vaccarella, M. Meregalli

Research output: Contribution to journalArticlepeer-review

Abstract

The respiratory effects of the oral administration of labetalol have been assessed in twenty-three patients with light respiratory impairment. Twelve of the patients were hypertensive (II WHO classification) (EH) and eleven affected by stable effort-induced angina (CAD). The drug induced a significant decrease in either systolic and diastolic blood pressures in EH patients and a significant improvement in effort tolerance in humans with coronary artery disease (CAD). Respiratory function did not worsen after treatment; on the contrary, the airways flow resistance parameters examined showed significant improvement. The findings seem to indicate a dissociation between the alpha- and beta-blocking effects of labetalol on bronchial smooth muscle and the opportunity to use the drug also in the treatment of patients with angina or hypertension affected by respiratory impairment.

Original languageEnglish
Pages (from-to)219-231
Number of pages13
JournalCurrent Therapeutic Research
Volume31
Issue number2
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Medicine(all)

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