Scambi respiratori durante colecistectomia laparoscopica e laparotomica.

Translated title of the contribution: Respiratory exchange during laparoscopic and laparotomic cholecystectomy

A. Casati, I. Salvo, E. Calderini, G. Valentini, A. Carozzo, E. Celeste, G. Torri

Research output: Contribution to journalArticle


The utility of laparoscopic cholecystectomy in reducing postoperative pain and patient's hospital discharge is already known. Nevertheless peritoneal gas insufflation required by surgical procedure can modify respiratory homeostasis during general anesthesia. The aim of this study was to evaluate the effect of laparoscopic cholecystectomy on pulmonary dead spaces and alveolar gas exchange during inhalation anesthesia compared with traditional laparotomic cholecystectomy. With the approval of Hospital Ethical Committee, thirty-one patients undergoing isoflurane general anesthesia for laparoscopic (CL-S, n = 16) and open (CL-T, n = 15) cholecystectomy were prospectively evaluated in order to asses modifications in physiological (VDphy/VT), anatomical (VDan/VT) and alveolar (VDalv/VT) dead space to tidal volume ratio, arterial to end-tidal carbon dioxide partial pressure difference [P(a-Et)CO2] and alveolar to arterial oxygen partial pressure difference (A-aDO2). Patients, 21-64 years-old, ASA I-II, had no cardiopulmonary diseases. The CL-S group required peritoneal insufflation of carbon dioxide with an intraabdominal pressure (IAP) of about 10-14 mmHg and antitrendelenburg positioning (15-20 degree). Expired gas measurements and arterial blood gas sample for pulmonary dead spaces and arterial to alveolar CO2 and O2 gradient calculation were performed 20 min after a steady state condition. VDphy/VT, VDalv/VT, P(a-Et)CO2 and A-aDO2 increased significantly in the CL-S compared to the CL-T group (p <0.05). No differences were found in the VDan/VT. These results can be explained by analteration of the ventilation to perfusion ratio (VA/Q) with an increase of high VA/Q regions due to the antitrendelenburg positioning with a redistribution of blood flow towards basal zones.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageItalian
Pages (from-to)81-85
Number of pages5
JournalMinerva Anestesiologica
Issue number3
Publication statusPublished - Mar 1994


ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Casati, A., Salvo, I., Calderini, E., Valentini, G., Carozzo, A., Celeste, E., & Torri, G. (1994). Scambi respiratori durante colecistectomia laparoscopica e laparotomica. Minerva Anestesiologica, 60(3), 81-85.