Insufficienza ventilatoria da miopatia in corso di sepsi severa.

Translated title of the contribution: Respiratory failure caused by myopathy in severe sepsis

G. Veschi, G. Zanforlin, G. Breda, E. Calappi, M. Cigada, A. Colombo, S. Marzorati, D. Mulazzi, A. Noto, A. Parma, S. Rotelli, A. Prelle, A. Cappellari, G. Iapichino

Research output: Contribution to journalArticle


OBJECTIVE: To describe a generalized myopathic disorder occurred in the convalescence phase of illness of a critically ill patient. SETTING: Neurological Intensive Care Unit. PATIENT: A 43-year-old man with acute leukoencephalopathy and severe sepsis complicated by sustained and prolonged cardiovascular, respiratory and renal failure. After 15 days of complete respiratory autonomy, the patient presented an acute ventilatory failure associated with generalized muscle weakness. Neither a relapse of sepsis nor neurological worsening were detected. MEASUREMENTS AND RESULTS: Electromyogram resulted in normal conduction velocity in both motor and sensitive nervous fibers. Muscular biopsy showed marked fiber size variability with several hypotrophic fibers type II fiber grouping, several areas of degeneration-necrosis with macrophage invasion, dishomogeneous oxidative enzymatic activity, no increase in glycogen or lipid content. CONCLUSIONS: These results excluded critical illness polyneuropathy and all the other known myopathies. Prolonged period of sepsis with multiple organ failure can result in a direct generalized myopathy. This possibility should be kept in mind while treating long term critically ill survivors.

Translated title of the contributionRespiratory failure caused by myopathy in severe sepsis
Original languageItalian
Pages (from-to)89-92
Number of pages4
JournalMinerva Anestesiologica
Issue number3
Publication statusPublished - Mar 1996

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Veschi, G., Zanforlin, G., Breda, G., Calappi, E., Cigada, M., Colombo, A., Marzorati, S., Mulazzi, D., Noto, A., Parma, A., Rotelli, S., Prelle, A., Cappellari, A., & Iapichino, G. (1996). Insufficienza ventilatoria da miopatia in corso di sepsi severa. Minerva Anestesiologica, 62(3), 89-92.