Respiratory fatigue in patients with acute cardiogenic pulmonary edema

F. Mojoli, L. Monti, M. Zanierato, C. Campana, S. Mediani, L. Tavazzi, A. Braschi

Research output: Contribution to journalArticlepeer-review


Evaluation of prevalence and features of respiratory fatigue (RF) in patients with acute cardiogenic pulmonary oedema (APE) Eighteen patients out of 65 consecutive APE were enrolled. All were treated with CPAP delivered by helmet added to medical therapy. RF (defined as an arterial CO 2 tension at admission higher than the expected) was diagnosed in nine patients. In these patients pH was lower (7.18 vs 7.35; P = 0.0001), base excess more negative (-9.9 vs -3.7 mEq/l; P = 0.005) and blood lactates more elevated (46.4 vs 20.8 mg/dl; P = 0.013) than in non-fatigued patients; after 3 h of treatment no more differences were found between the two groups. At admission RF patients had lower mean echocardiographic left ventricular ejection fraction (LVEF): 30.7 ± 12.4% vs 39.1 ± 12.8%. After 24 h LVEF increased significantly (P = 0.0034) in RF patients, whereas didn't in non-fatigued ones (P = 0.19). About 50% of patients with APE present respiratory fatigue. These patients are characterized by a pH

Original languageEnglish
JournalEuropean Heart Journal, Supplement
Issue number6
Publication statusPublished - Nov 2004


  • Acute pulmonary edema
  • Alveolar ventilation
  • CO removal
  • Continuous positive airway pressure
  • Respiratory fatigue

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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