Pulmonary function was evaluated by means of a battery of measures, including Maximal Voluntary Ventilation, Forced Vital Capacity, Forced Expiratory Volume, in 71 consecutive patients with primary and secondary progressive Multiple Sclerosis (MS). Respiratory impairment was common in MS patients, occurring in 69% of all patients. Cerebellar and mental impairment were significantly negatively associated with pulmonary function. The presence of severe cerebellar signs was associated with a very high risk of occurrence of respiratory impairment (OR = 6.24; 95% Cl 1.71-22.82). Other significant variables were severity of illness (OR= 4.71; 95% Cl 1.42-15.66) and long disease duration (OR = 3.39; 95% Cl 1.01-11.42). In our study the association of cerebellar impairment with respiratory alterations suggests that muscle coordination may play an important role in determining the respiratory dysfunction in MS patients.
|Translated title of the contribution||Respiratory impairment and multiple sclerosis: Report on 71 patients|
|Number of pages||4|
|Journal||Nuova Rivista di Neurologia|
|Publication status||Published - Jul 1999|
ASJC Scopus subject areas
- Clinical Neurology