Deficit respiratorio nella sclerosi multipla: Studio su 71 pazienti

Translated title of the contribution: Respiratory impairment and multiple sclerosis: Report on 71 patients

Maria Grazia Grasso, Laura Guidi, Sergio Lubich, Dagmar Rinnenburger, Stefano Paolucci

Research output: Contribution to journalArticlepeer-review


Pulmonary function was evaluated by means of a battery of measures, including Maximal Voluntary Ventilation, Forced Vital Capacity, Forced Expiratory Volume, in 71 consecutive patients with primary and secondary progressive Multiple Sclerosis (MS). Respiratory impairment was common in MS patients, occurring in 69% of all patients. Cerebellar and mental impairment were significantly negatively associated with pulmonary function. The presence of severe cerebellar signs was associated with a very high risk of occurrence of respiratory impairment (OR = 6.24; 95% Cl 1.71-22.82). Other significant variables were severity of illness (OR= 4.71; 95% Cl 1.42-15.66) and long disease duration (OR = 3.39; 95% Cl 1.01-11.42). In our study the association of cerebellar impairment with respiratory alterations suggests that muscle coordination may play an important role in determining the respiratory dysfunction in MS patients.

Translated title of the contributionRespiratory impairment and multiple sclerosis: Report on 71 patients
Original languageItalian
Pages (from-to)132-135
Number of pages4
JournalNuova Rivista di Neurologia
Issue number4
Publication statusPublished - Jul 1999

ASJC Scopus subject areas

  • Clinical Neurology

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