Respiratory mechanics in COPD patients who failed non-invasive ventilation: Role of intrinsic PEEP

Vittorio Antonaglia; Massimo Ferluga; Guido Capitanio; Umberto Lucangelo; Fulvia Piller; Erik Roman-Pognuz; Bruno Biancardi; Giuseppe Davide Caggegi; Walter A. Zin

doi:10.1016/j.resp.2012.07.009

Respiratory mechanics in COPD patients who failed non-invasive ventilation: Role of intrinsic PEEP

Vittorio Antonaglia, Massimo Ferluga, Guido Capitanio, Umberto Lucangelo, Fulvia Piller, Erik Roman-Pognuz, Bruno Biancardi, Giuseppe Davide Caggegi, Walter A. Zin

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Research output: Contribution to journal › Article › peer-review

Abstract

Non-invasive positive pressure ventilation (NPPV) is the first choice to treat exacerbations in COPD patients. NPPV can fail owing to different causes related to gas exchange impairment (RF group) or intolerance (INT group). To assess if the respiratory mechanical properties and the ratio between the dynamic and static intrinsic positive end-expiratory pressure (PEEP_i,dyn/PEEP_i,stat), reflecting lung mechanical inequalities, were different between groups, 29 COPD patients who failed NPPV (15 RF and 14 INT) were studied, early after the application of invasive ventilation. Blood gas analysis, clinical status, and mechanical properties were measured. pH was higher in INT patients before intubation (pi,dyn/PEEP_i,stat was found higher in INT group with (p=0.021) and without PEEP (ZEEP, pi,dyn/PEEP_i,stat was exponentially associated with the duration of NPPV in INT group (p=0.011). INT and RF patients had similar impairment of respiratory system resistance and elastance.

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	Respiratory Physiology and Neurobiology
Volume	184
Issue number	1
DOIs	https://doi.org/10.1016/j.resp.2012.07.009
Publication status	Published - Oct 15 2012

Keywords

Acute exacerbation of COPD
Invasive ventilation
Lung mechanical inequalities
Respiratory mechanical behavior
Viscoelasticity

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine
Neuroscience(all)

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Respiratory mechanics in COPD patients who failed non-invasive ventilation : Role of intrinsic PEEP. / Antonaglia, Vittorio; Ferluga, Massimo; Capitanio, Guido; Lucangelo, Umberto; Piller, Fulvia; Roman-Pognuz, Erik; Biancardi, Bruno; Caggegi, Giuseppe Davide; Zin, Walter A.

In: Respiratory Physiology and Neurobiology, Vol. 184, No. 1, 15.10.2012, p. 35-40.

Research output: Contribution to journal › Article › peer-review

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