Respiratory patterns during sleep in mitochondrial myopathies with ophthalmoplegia

R. Manni, G. Piccolo, P. Banfi, I. Cerveri, C. Bruschi, C. Zoia, A. Tartara

Research output: Contribution to journalArticlepeer-review

Abstract

Nocturnal polygraphic recordings (electroencephalography, electro-oculography, submental and intercostal muscle electromyography, electrocardiography, respiration by thoracic strain gauges and oronasal thermistors) with continuous monitoring of arterial oxyhemoglobin saturation by pulse oximeter were performed in 8 patients with ophthalmoplegia plus. All patients except 1 had normal blood gas values and normal lung volumes associated with a diminished ventilatory response to inhaled CO2 during wakefulness. Four patients showed pathological sleep-related breathing patterns consisting of sleep apneic polygraphic tracings mainly of the central type or of REM-related hypoventilation episodes. It is suggested that these disorders in patients with ophthalmoplegia plus may have a central origin and be related to the underlying metabolic disturbance.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalEuropean Neurology
Volume31
Issue number1
Publication statusPublished - 1991

Keywords

  • Kearns-Sayre syndrome
  • mitochondrial myopathies
  • sleep-related breathing disorders

ASJC Scopus subject areas

  • Clinical Neurology

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