Response of glucagon and insulin secretion to insulin- induced hypoglycaemia in Type I diabetic patients after pancreatic transplantation

E. Bosi; P. M. Piatti; A. Secchi; L. D. Monti; J. Traeger; J. M. Dubernard; G. Pozza

Response of glucagon and insulin secretion to insulin- induced hypoglycaemia in Type I diabetic patients after pancreatic transplantation

E. Bosi, P. M. Piatti, A. Secchi, L. D. Monti, J. Traeger, J. M. Dubernard, G. Pozza

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The glucagon and insulin (measured as C-peptide) secretion responses to insulin-induced hypoglycaemia were studied in 6 Type I diabetic patients after successful segmental-pancreatic and renal transplantation. At the time of the study all the patients were independent of insulin and with normal fasting blood glucose (BG) and glycosylated haemoglobin values. Insulin-induced (0.075 IU/kg i.v. insulin over 60 min) hypoglycaemia (38.8 ± 3.23 mg/dl at 60 min) was followed by a spontaneous return of BG to normal in 4 patients, while the remainder required i.v. glucose. Plasma glucagon levels rose in 5 out of 6 patients from basal values of 122.0 ± 5.7 to a peak of 188.0 ± 15.2 pg/ml (p

Original language	English
Pages (from-to)	21-27
Number of pages	7
Journal	Diabetes, Nutrition and Metabolism - Clinical and Experimental
Volume	1
Issue number	1
Publication status	Published - 1988

ASJC Scopus subject areas

Food Science
Endocrinology
Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Internal Medicine

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Response of glucagon and insulin secretion to insulin- induced hypoglycaemia in Type I diabetic patients after pancreatic transplantation. / Bosi, E.; Piatti, P. M.; Secchi, A.; Monti, L. D.; Traeger, J.; Dubernard, J. M.; Pozza, G.

In: Diabetes, Nutrition and Metabolism - Clinical and Experimental, Vol. 1, No. 1, 1988, p. 21-27.

Research output: Contribution to journal › Article › peer-review

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