RESPONSE OF HUMAN-IMMUNODEFICIENCY-VIRUS-ASSOCIATED NEUROLOGICAL DISEASE TO 3'-AZIDO-3'-DEOXYTHYMIDINE

Robert Yarchoan, Pim Brouwers, A. Robert Spitzer, Jordan Grafman, Bijan Safai, CarloF Perno, StevenM Larson, Gary Berg, MargaretA Fischl, Alison Wichman, RoseV Thomas, Arturo Brunetti, PeterJ Schmidt, CharlesE Myers, Samuel Broder

Research output: Contribution to journalArticle

Abstract

Four patients with human-immunodeficiency-virus-associated neurological disease were treated with 3'-azido-3'-deoxythymidine (AZT). Three (two with chronic dementia, and one with chronic dementia and peripheral neuropathy) improved as assessed by clinical examination, psychometric tests, nerve conduction studies, and/or positron emission tomography; there was no improvement in the fourth patient who presented with paraplegia. These results support the hypothesis that certain AIDS-virus-associated neurological abnormalities are reversible by antiretroviral chemotherapy.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalLancet
Volume329
Issue number8525
DOIs
Publication statusPublished - Jan 17 1987

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yarchoan, R., Brouwers, P., Robert Spitzer, A., Grafman, J., Safai, B., Perno, C., Larson, S., Berg, G., Fischl, M., Wichman, A., Thomas, R., Brunetti, A., Schmidt, P., Myers, C., & Broder, S. (1987). RESPONSE OF HUMAN-IMMUNODEFICIENCY-VIRUS-ASSOCIATED NEUROLOGICAL DISEASE TO 3'-AZIDO-3'-DEOXYTHYMIDINE. Lancet, 329(8525), 132-135. https://doi.org/10.1016/S0140-6736(87)91968-4