Response of non-Hodgkin lymphoma to radiation therapy: Early and long-term assessment with H-1 MR spectroscopic imaging

Alberto Bizzi, Benjamin Movsas, Gioacchino Tedeschi, Carrie L. Phillips, Paul Okunieff, Jeffry R. Alger, Giovanni Di Chiro

Research output: Contribution to journalArticlepeer-review


PURPOSE: To determine whether proton magnetic resonance (MR) spectroscopic imaging is a sensitive technique for defining tumor extent and assessing response of cerebral lymphoma to therapy. MATERIALS AND METHODS: Four hydrogen-1 MR spectroscopic imaging studies were performed in a patient with non-Hodgkin lymphoma (NHL) before, during, and after radiation therapy and at follow-up at 33 months after diagnosis of the recurrence of disease. The patient had a single, large lesion in the brain and underwent hyperfractionated radiation therapy for 4 weeks. A series of MR images was also obtained. RESULTS: The pretreatment study showed a lesion with a distinct spectral pattern: marked elevation of choline and lipids and great reduction of creatine and N-acetylaspartate. During and after treatment, H-1 MR spectroscopic images depicted a progressive reduction of the abnormal choline and lipid signals. Thirtythree months after treatment, multiple-section H-1 MR spectroscopic images showed normal spectral patterns in all sections examined. CONCLUSION: H-1 MR spectroscopy may contribute to the neuroradiologic evaluation of NHL and, in particular, may be useful in monitoring therapeutic response.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
Issue number1
Publication statusPublished - Jan 1995


  • Brain neoplasms, emission CT, 132.12145
  • Brain neoplasms, secondary, 132.343
  • Hodgkin disease, therapeutic radiology, 132.343
  • Magnetic resonance (MR), spectroscopy, 132.12145

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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