Abstract
PURPOSE: To determine whether proton magnetic resonance (MR) spectroscopic imaging is a sensitive technique for defining tumor extent and assessing response of cerebral lymphoma to therapy. MATERIALS AND METHODS: Four hydrogen-1 MR spectroscopic imaging studies were performed in a patient with non-Hodgkin lymphoma (NHL) before, during, and after radiation therapy and at follow-up at 33 months after diagnosis of the recurrence of disease. The patient had a single, large lesion in the brain and underwent hyperfractionated radiation therapy for 4 weeks. A series of MR images was also obtained. RESULTS: The pretreatment study showed a lesion with a distinct spectral pattern: marked elevation of choline and lipids and great reduction of creatine and N-acetylaspartate. During and after treatment, H-1 MR spectroscopic images depicted a progressive reduction of the abnormal choline and lipid signals. Thirtythree months after treatment, multiple-section H-1 MR spectroscopic images showed normal spectral patterns in all sections examined. CONCLUSION: H-1 MR spectroscopy may contribute to the neuroradiologic evaluation of NHL and, in particular, may be useful in monitoring therapeutic response.
| Original language | English |
|---|---|
| Pages (from-to) | 271-276 |
| Number of pages | 6 |
| Journal | Radiology |
| Volume | 194 |
| Issue number | 1 |
| Publication status | Published - Jan 1995 |
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Keywords
- Brain neoplasms, emission CT, 132.12145
- Brain neoplasms, secondary, 132.343
- Hodgkin disease, therapeutic radiology, 132.343
- Magnetic resonance (MR), spectroscopy, 132.12145
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
Response of non-Hodgkin lymphoma to radiation therapy : Early and long-term assessment with H-1 MR spectroscopic imaging. / Bizzi, Alberto; Movsas, Benjamin; Tedeschi, Gioacchino; Phillips, Carrie L.; Okunieff, Paul; Alger, Jeffry R.; Di Chiro, Giovanni.
In: Radiology, Vol. 194, No. 1, 01.1995, p. 271-276.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Response of non-Hodgkin lymphoma to radiation therapy
T2 - Early and long-term assessment with H-1 MR spectroscopic imaging
AU - Bizzi, Alberto
AU - Movsas, Benjamin
AU - Tedeschi, Gioacchino
AU - Phillips, Carrie L.
AU - Okunieff, Paul
AU - Alger, Jeffry R.
AU - Di Chiro, Giovanni
PY - 1995/1
Y1 - 1995/1
N2 - PURPOSE: To determine whether proton magnetic resonance (MR) spectroscopic imaging is a sensitive technique for defining tumor extent and assessing response of cerebral lymphoma to therapy. MATERIALS AND METHODS: Four hydrogen-1 MR spectroscopic imaging studies were performed in a patient with non-Hodgkin lymphoma (NHL) before, during, and after radiation therapy and at follow-up at 33 months after diagnosis of the recurrence of disease. The patient had a single, large lesion in the brain and underwent hyperfractionated radiation therapy for 4 weeks. A series of MR images was also obtained. RESULTS: The pretreatment study showed a lesion with a distinct spectral pattern: marked elevation of choline and lipids and great reduction of creatine and N-acetylaspartate. During and after treatment, H-1 MR spectroscopic images depicted a progressive reduction of the abnormal choline and lipid signals. Thirtythree months after treatment, multiple-section H-1 MR spectroscopic images showed normal spectral patterns in all sections examined. CONCLUSION: H-1 MR spectroscopy may contribute to the neuroradiologic evaluation of NHL and, in particular, may be useful in monitoring therapeutic response.
AB - PURPOSE: To determine whether proton magnetic resonance (MR) spectroscopic imaging is a sensitive technique for defining tumor extent and assessing response of cerebral lymphoma to therapy. MATERIALS AND METHODS: Four hydrogen-1 MR spectroscopic imaging studies were performed in a patient with non-Hodgkin lymphoma (NHL) before, during, and after radiation therapy and at follow-up at 33 months after diagnosis of the recurrence of disease. The patient had a single, large lesion in the brain and underwent hyperfractionated radiation therapy for 4 weeks. A series of MR images was also obtained. RESULTS: The pretreatment study showed a lesion with a distinct spectral pattern: marked elevation of choline and lipids and great reduction of creatine and N-acetylaspartate. During and after treatment, H-1 MR spectroscopic images depicted a progressive reduction of the abnormal choline and lipid signals. Thirtythree months after treatment, multiple-section H-1 MR spectroscopic images showed normal spectral patterns in all sections examined. CONCLUSION: H-1 MR spectroscopy may contribute to the neuroradiologic evaluation of NHL and, in particular, may be useful in monitoring therapeutic response.
KW - Brain neoplasms, emission CT, 132.12145
KW - Brain neoplasms, secondary, 132.343
KW - Hodgkin disease, therapeutic radiology, 132.343
KW - Magnetic resonance (MR), spectroscopy, 132.12145
UR - http://www.scopus.com/inward/record.url?scp=0028950022&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028950022&partnerID=8YFLogxK
M3 - Article
VL - 194
SP - 271
EP - 276
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 1
ER -