Response of renal transplanted patients to oral calcium load

G. Graziani, C. Castelnovo, A. Aroldi, S. Adami, E. Vigano, S. Casati, A. De Vecchi

Research output: Contribution to journalArticle

Abstract

In a previous study we demonstrated that cyclosporin-treated renal transplanted patients have a reduced 1,25(OH)2D3 synthesis in comparison with azathioprine-treated transplanted patients. To assess the impact of this defect on intestinal calcium transport we compared the plasma calcium variation and the urinary calcium excretion in 14 cyclosporin-treated and in 12 azathioprine-treated patients, in fasting conditions and 4 hours after an oral calcium load (1 g). In ten cyclosporin patients we also correlated cyclosporin plasma values with plasma 1,25(OH)2D3 values before and after a 25(OH)D3 oral load. After the oral calcium load, plasma and urinary calcium increased significantly in the azathioprine group, while remaining unchanged in the cyclosporin group. A negative correlation between plasma concentrations of cyclosporin and the increment in 1,25(OH)2D3 after 25(OH)D3 oral load was also observed. Thus, our data suggest that cyclosporin impairs 1-alpha hydroxylase activity and alters the response to an oral calcium load.

Original languageEnglish
Pages (from-to)531-534
Number of pages4
JournalNephrology Dialysis Transplantation
Volume5
Issue number7
Publication statusPublished - 1990

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Keywords

  • Calcium metabolism
  • Cyclosporin A
  • Renal transplantation
  • Vitamin D

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Graziani, G., Castelnovo, C., Aroldi, A., Adami, S., Vigano, E., Casati, S., & De Vecchi, A. (1990). Response of renal transplanted patients to oral calcium load. Nephrology Dialysis Transplantation, 5(7), 531-534.