Response to antiretroviral treatment after failure of NNRTI plus NRTIs-based therapy. Data from the ARCA Collaborative Group

Elena Seminari, Annalisa de Silvestri, Genny Meini, Annapaola Callegaro, Enzo Boeri, Grazia Punzi, Nicola Gianotti, Bianca Bruzzone, Carmine Tinelli, Paolo Grossi

Research output: Contribution to journalArticle

Abstract

Objective: The aim of the present study was to evaluate the virological response to a new antiretroviral treatment (ART2) after failure of a nonnucleoside reverse transcriptase inhibitor (NNRTI) plus two nucleoside reverse transcriptase inhibitors (NRTIs)-containing regimen. Design: Retrospective observational study based on the Italian ARCA cohort database. Adult patients were included if they had a virological failure (defined as plasma viral load above 500 copies/ml in two subsequent visits) while on a treatment with one NNRTI plus 2 NRTIs, had an available HIV genotype. Results: Patients on ART2 were followed up for 791 person/year and median follow up was 10.8 months(IQR 5.2-26). Variables associated with reduced risk of ART2 virological failure at univariable analysis had started the treatment in recent years (HR 0.90; 95% CI 0.86-0.94, p

Original languageEnglish
Pages (from-to)334-340
Number of pages7
JournalCurrent HIV Research
Volume10
Issue number4
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Drug resistance
  • Genotypic susceptibility score
  • HIV infection
  • NNRTI failure
  • Rescue therapy
  • Viral rebound

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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