Response to chemotherapy in gastric adenocarcinoma with diffusion-weighted MRI and 18F-FDG-PET/CT: Correlation of apparent diffusion coefficient and partial volume corrected standardized uptake value with histological tumor regression grade

Francesco Giganti, Francesco De Cobelli, Carla Canevari, Elena Orsenigo, Francesca Gallivanone, Antonio Esposito, Isabella Castiglioni, Alessandro Ambrosi, Luca Albarello, Elena Mazza, Luigi Gianolli, Carlo Staudacher, Alessandro Del Maschio

Research output: Contribution to journalArticle

Abstract

Purpose: To assess whether changes in diffusionweighted MRI (DW-MRI) and 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), correlate with treatment response to neoadjuvant therapy (NT), as expressed by tumor regression grade (TRG), from locally advanced gastric adenocarcinoma (GA).

Materials and Methods: Seventeen patients underwent both DW-MRI and 18F-FDG-PET/CT scans before and after the end of NT. Apparent diffusion coefficient (ADC) and mean standardized uptake value (SUV) corrected for partial volume effect (PVC-SUVBW-mean) were evaluated and compared with histopathological TRG.

Results: Pre- And post-NT and percentage changes forADC and PVC-SUVBW-mean were assessed. Post-NT ADC and DADC showed a significant inverse correlation with TRG (r=-0.71; P=0.0011 and r=-0.78; P=0.00020, respectively) and significant differences in their mean values were found between responders (TRG 1-2-3) and nonresponders (TRG 4-5) (P=0.0009; P=0.000082, respectively). No correlations with TRG were found for pre-NT ADC and for all PVC-SUVBW-mean values as well as between DADC and D PVC-SUVBW-mean.

Conclusion: DW-MRI seems more accurate than 18FFDG-PET/CT and ADC modifications may represent a reproducible tool to assess tumor response for GA.

Original languageEnglish
Pages (from-to)1147-1157
Number of pages11
JournalJournal of Magnetic Resonance Imaging
Volume40
Issue number5
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • ADC
  • DW-MRI
  • Gastric cancer
  • PET/MRI
  • PVC-SUV
  • TRG

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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