TY - JOUR
T1 - Response to chemotherapy in gastric adenocarcinoma with diffusion-weighted MRI and 18F-FDG-PET/CT
T2 - Correlation of apparent diffusion coefficient and partial volume corrected standardized uptake value with histological tumor regression grade
AU - Giganti, Francesco
AU - De Cobelli, Francesco
AU - Canevari, Carla
AU - Orsenigo, Elena
AU - Gallivanone, Francesca
AU - Esposito, Antonio
AU - Castiglioni, Isabella
AU - Ambrosi, Alessandro
AU - Albarello, Luca
AU - Mazza, Elena
AU - Gianolli, Luigi
AU - Staudacher, Carlo
AU - Del Maschio, Alessandro
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Purpose: To assess whether changes in diffusionweighted MRI (DW-MRI) and 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), correlate with treatment response to neoadjuvant therapy (NT), as expressed by tumor regression grade (TRG), from locally advanced gastric adenocarcinoma (GA).Materials and Methods: Seventeen patients underwent both DW-MRI and 18F-FDG-PET/CT scans before and after the end of NT. Apparent diffusion coefficient (ADC) and mean standardized uptake value (SUV) corrected for partial volume effect (PVC-SUVBW-mean) were evaluated and compared with histopathological TRG.Results: Pre- And post-NT and percentage changes forADC and PVC-SUVBW-mean were assessed. Post-NT ADC and DADC showed a significant inverse correlation with TRG (r=-0.71; P=0.0011 and r=-0.78; P=0.00020, respectively) and significant differences in their mean values were found between responders (TRG 1-2-3) and nonresponders (TRG 4-5) (P=0.0009; P=0.000082, respectively). No correlations with TRG were found for pre-NT ADC and for all PVC-SUVBW-mean values as well as between DADC and D PVC-SUVBW-mean.Conclusion: DW-MRI seems more accurate than 18FFDG-PET/CT and ADC modifications may represent a reproducible tool to assess tumor response for GA.
AB - Purpose: To assess whether changes in diffusionweighted MRI (DW-MRI) and 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), correlate with treatment response to neoadjuvant therapy (NT), as expressed by tumor regression grade (TRG), from locally advanced gastric adenocarcinoma (GA).Materials and Methods: Seventeen patients underwent both DW-MRI and 18F-FDG-PET/CT scans before and after the end of NT. Apparent diffusion coefficient (ADC) and mean standardized uptake value (SUV) corrected for partial volume effect (PVC-SUVBW-mean) were evaluated and compared with histopathological TRG.Results: Pre- And post-NT and percentage changes forADC and PVC-SUVBW-mean were assessed. Post-NT ADC and DADC showed a significant inverse correlation with TRG (r=-0.71; P=0.0011 and r=-0.78; P=0.00020, respectively) and significant differences in their mean values were found between responders (TRG 1-2-3) and nonresponders (TRG 4-5) (P=0.0009; P=0.000082, respectively). No correlations with TRG were found for pre-NT ADC and for all PVC-SUVBW-mean values as well as between DADC and D PVC-SUVBW-mean.Conclusion: DW-MRI seems more accurate than 18FFDG-PET/CT and ADC modifications may represent a reproducible tool to assess tumor response for GA.
KW - ADC
KW - DW-MRI
KW - Gastric cancer
KW - PET/MRI
KW - PVC-SUV
KW - TRG
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U2 - 10.1002/jmri.24464
DO - 10.1002/jmri.24464
M3 - Article
C2 - 24214734
AN - SCOPUS:84913613051
VL - 40
SP - 1147
EP - 1157
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
IS - 5
ER -