Response to DNA-damaging agents in cultured cells from patients with X-linked duchenne muscular dystrophy phenotype: male DMD, female DMD, possible carriers

Laura Barsi, Giovanni Meola, Mariaelena Velicogna, Cristiana Bonifati, Anna Maria Fuhrman Conti, Guglielmo Scarlato

Research output: Contribution to journalArticlepeer-review

Abstract

Using blood cultures the response to gamma (γ) radiation was examined in a male DMD and his mother, in a female DMD and her mother and in a normal control. In a series of experiments chromosome aberrations were determined after 3 separate γ-irradiation dose levels: 0, 150, 300 rads. The DMD patients showed a response to ionising radiations different from control, in fact the percentage of aberrations was lower than the control. In this preliminary study a slight difference between normal and possible carriers was also found.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalCytotechnology
Volume1
Issue number1
DOIs
Publication statusPublished - Oct 1987

Keywords

  • blood cultures
  • carriers
  • DNA-damaging agents
  • duchenne muscular dystrophy
  • ionising radiations

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Biotechnology

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